Chemical Engineer - Pharmaceutical Synthesis

Placements24; Benoni; On-site; ZAR 600,000 - 900,000; Full time

Benefits offered by this job

Competitive package

On-site Benoni facilities

Professional development

Collaborative environment

Job summary

Placements24 is seeking a dedicated Chemical Engineer for their Benoni synthesis operations team. This on-site role focuses on scaling up APIs, optimizing processes, and ensuring safe, compliant production within cGMP guidelines.

You will collaborate with chemists, process scientists, and QA to move from lab to pilot and production scales, validate new procedures, and implement CAPAs while maintaining product quality and efficiency.

Qualifications

• Bachelor's or Master's degree in Chemical Engineering.
• 5+ years in chemical process development and scale-up for pharma.
• Experience with cGMP and pharmaceutical manufacturing environments.
• Strong problem-solving and communication skills.

Responsibilities

• Scale up chemical synthesis from lab to pilot and production scales.
• Optimize reaction conditions, work-up procedures, and isolation techniques to improve yield and purity.
• Develop and validate new process operating procedures and batch records.
• Conduct PHAs and implement safety protocols for chemical synthesis operations.
• Design, specify, and commission new process equipment relevant to pharmaceutical synthesis.
• Troubleshoot process deviations and implement CAPAs.
• Ensure all activities comply with cGMP and regulatory guidelines.
• Collaborate with R&D chemists, analytical scientists, and quality assurance teams.
• Monitor and control process parameters to ensure consistent product quality.
• Contribute to continuous improvement initiatives within manufacturing.

Skills

Process scale-up

cGMP compliance

Process safety

Data analysis

Communication

Education

Bachelor's or Master's degree in Chemical Engineering

Job description

About the Role

Our client, a renowned pharmaceutical manufacturer, is seeking a dedicated Chemical Engineer to join their synthesis operations team in **Benoni**. This is an on-site position where you will apply your expertise to optimize and scale up chemical synthesis processes for active pharmaceutical ingredients (APIs). You will work closely with chemists and process scientists to ensure efficient, safe, and compliant production. This is an excellent opportunity for an engineer passionate about the pharmaceutical industry and eager to contribute to the development and manufacturing of life-saving medications in the **Gauteng** province. The successful candidate will possess strong knowledge of organic synthesis scale-up, process safety, and regulatory requirements (cGMP).

Key Responsibilities

• Scale up chemical synthesis processes from laboratory to pilot plant and commercial manufacturing scales.
• Optimize reaction conditions, work-up procedures, and isolation techniques to improve yield, purity, and efficiency.
• Develop and validate new process operating procedures and batch records.
• Conduct Process Hazard Analyses (PHAs) and implement safety protocols for chemical synthesis operations.
• Design, specify, and commission new process equipment relevant to pharmaceutical synthesis.
• Troubleshoot process deviations and implement corrective and preventive actions (CAPAs).
• Ensure all activities comply with current Good Manufacturing Practices (cGMP) and regulatory guidelines.
• Collaborate with R&D chemists, analytical scientists, and quality assurance teams.
• Monitor and control process parameters to ensure consistent product quality.
• Contribute to continuous improvement initiatives within the manufacturing department.

Requirements

• Bachelor's or Master's degree in Chemical Engineering.
• Minimum of 5 years of experience in chemical process development and scale-up, with a focus on pharmaceutical or fine chemical synthesis.
• Strong understanding of organic chemistry principles and reaction kinetics.
• Experience with cGMP regulations and pharmaceutical manufacturing environments.
• Familiarity with process safety assessments and management.
• Proficiency in process simulation and data analysis tools.
• Excellent problem-solving skills and attention to detail.
• Strong written and verbal communication skills.
• Ability to work effectively in a fast-paced, team-oriented environment.

Benefits

• Competitive salary and comprehensive benefits package.
• Opportunity to work in the dynamic pharmaceutical sector.
• Contribute to the manufacturing of critical medicines.
• On-site role with access to advanced facilities in **Benoni**.
• Professional development and training opportunities.
• Supportive and collaborative work environment.
• Be part of a company dedicated to improving global health outcomes.