VP, Technical Operations — Vaccine Manufacturing & Scale-Up

Vaxart, Inc.; South San Francisco (CA); On-site; USD 300,000 - 345,000; Full time

Benefits offered by this job

Health plan

Bonus program

Stock options

401(k) matching

Tuition assistance

Commuter benefits

Work-life balance

Job summary

Vaxart, Inc. is seeking a Vice President, Technical Operations to lead engineering, qualification and validation, facilities, maintenance, external supply, and CMC project management in South San Francisco.

This onsite role reports to the CTO and drives scalable, compliant manufacturing capabilities for oral pill vaccines across development stages. The successful candidate will translate science into robust operations, manage internal teams and external partners, and build a cost-conscious,

Qualifications

• Bachelor’s degree in engineering, life sciences, or related technical discipline; advanced degree preferred.
• 20+ years biotechnology/pharma experience with 15+ years leadership in Technical Operations, CMC, manufacturing, or related function.
• Experience with technology transfer, scale-up, validation, clinical supply, and commercial readiness.
• Deep working knowledge of cGMP, FDA, EMA, ICH; experience preparing for regulatory inspections and partner audits.
• Experience authoring and reviewing CMC content for regulatory submissions and responding to health-authority questions.

Responsibilities

• Oversee facilities, utilities and equipment from concept through commissioning and sustained operation.
• Set engineering, qualification, and validation strategies for internal and external operations across development phases.
• Develop scalable external manufacturing and supply approaches for oral vaccines with emphasis on quality, safety, accessibility, and distribution.
• Collaborate with Quality to maintain compliant systems and data-driven decisions across engineering and supply.
• Ensure CMC compliance with FDA/EMA/ICH and maintain inspection readiness across internal and external networks.
• Provide CMC leadership for regulatory submissions, health-authority interactions, inspections, and responses.
• Build a high-performing, collaborative organization reflecting Vaxart’s principles of fast execution, quality, and innovation.
• Establish performance measures for engineering, supply reliability, and partner performance to drive continuous improvement.
• Lead technology transfers from planning through regulatory approval and knowledge transfer across sites.

Job description

Vaxart, Inc. is seeking a Vice President, Technical Operations to lead engineering, qualification and validation, facilities, maintenance, external supply, and CMC project management in South San Francisco.

This onsite role reports to the CTO and drives scalable, compliant manufacturing capabilities for oral pill vaccines across development stages. The successful candidate will translate science into robust operations, manage internal teams and external partners, and build a cost-conscious,