VP, Early Detection Informatics & Data Science

Caris Life Sciences; Phoenix (AZ); On-site; USD 220,000 - 320,000; Full time

Job summary

Caris Life Sciences seeks a senior leader to drive early cancer detection informatics, overseeing production bioinformatics pipelines, data integrity, and regulatory compliance. You will define data models, orchestrate workflows, and mentor a high-performing team to translate multi-omic data into clinically actionable insights.

The role emphasizes scalable cloud-based strategies, governance, and collaboration with executive and clinical teams, with on-site work in Phoenix, AZ.

Qualifications

• PhD or equivalent in a STEM field with extensive data science or bioinformatics experience.
• 10+ years building/operating production-grade analytics or bioinformatics in diagnostics, medical devices, pharma, or high-throughput labs.
• Proficiency in Python, SQL, ETL/ELT, orchestration, APIs, and scalable workflows.
• Experience with bioinformatics pipelines and NGS platforms (Illumina).
• Regulated environments knowledge: GxP, CLIA, CAP, FDA quality systems.
• Leadership experience managing technical teams for cross-functional delivery.

Responsibilities

• Provide executive oversight for design, reliability, and scalability of bioinformatics pipelines across sequencing platforms and clinical data sources.
• Oversee development, orchestration, and production deployment of bioinformatics workflows for early detection assays.
• Establish canonical data models, metrics, dataset versioning, and change control across R&D, validation, and production environments.
• Ensure data integrity, auditability, traceability, and compliance with GxP and regulatory expectations.
• Define cloud-based or hybrid compute strategies enabling high-throughput analysis and model retraining.
• Own SLAs, uptime targets, monitoring, alerting, and turnaround time for production pipelines.
• Build, mentor, and lead a high-performing informatics team; set OKRs, budgets, roadmaps.
• Establish governance models and stakeholder engagement frameworks; foster scientific rigor and continuous improvement.

Skills

Python

SQL

ETL/ELT

Orchestration

APIs

Scalable workflows

Bioinformatics

Next-generation sequencing

Education

PhD in Data Science / Bioinformatics / Biostatistics / CS / Biomedical Engineering

Tools

AWS SageMaker

S3

Athena

DRAGEN

Job description

Caris Life Sciences seeks a senior leader to drive early cancer detection informatics, overseeing production bioinformatics pipelines, data integrity, and regulatory compliance. You will define data models, orchestrate workflows, and mentor a high-performing team to translate multi-omic data into clinically actionable insights.

The role emphasizes scalable cloud-based strategies, governance, and collaboration with executive and clinical teams, with on-site work in Phoenix, AZ.