VP, Clinical Pharmacology — Oncology PK/PD & DMPK Strategy

RA Cap; Boston (MA); On-site; USD 275,000 - 345,000; Full time

Benefits offered by this job

Health plan

401k plan

Life Insurance

Paid time off

Family leave

Disability insurance

Training & development

Free food & snacks

Wellness resources

Stock option plan

Job summary

Frontier is seeking a VP, Clinical Pharmacology to lead strategy across our oncology portfolio, spanning nonclinical PK/PD/ADME, and clinical pharmacology for active trials. This senior role partners with Clinical Development, Regulatory, Biometrics, and CMC to shape dose selection, regulatory strategy, and trial design.

The successful candidate will build the function, manage CROs, and eventually lead a small internal team while collaborating with FDA and other health authorities.

Qualifications

• PhD, PharmD or equivalent advanced degree in pharmacology or related field.
• 15+ years in clinical pharmacology within biotech/pharma with DMPK oversight.
• Oncology experience and cross-functional collaboration required.

Responsibilities

• Lead clinical pharmacology strategy across trials, including dose selection and exposure-response analyses.
• Oversee nonclinical and clinical bioanalytical strategies and execution.
• Oversee DMPK activities in support of program needs.
• Provide input into CMC decisions, including formulation strategy and DDIs.
• Develop content for regulatory submissions (IND/CTA) with Regulatory Affairs.
• Represent clinical pharmacology in FDA interactions and briefing documents.
• Apply MIDD approaches, PBPK modeling, and biomarker strategy.
• Partner with Clinical Development, Biometrics, Regulatory, and CMC to embed pharmacology in trial design.
• Lead CRO relationships and eventually build an internal team for pharmacology/DMPK.
• Manage CRO relationships supporting pharmacology and DMPK activities.

Skills

Strategic leadership

Cross-functional collab

CRO management

Regulatory liaison

Pharmacology expertise

Education

PhD/PharmD or equivalent

Job description

Frontier is seeking a VP, Clinical Pharmacology to lead strategy across our oncology portfolio, spanning nonclinical PK/PD/ADME, and clinical pharmacology for active trials. This senior role partners with Clinical Development, Regulatory, Biometrics, and CMC to shape dose selection, regulatory strategy, and trial design.

The successful candidate will build the function, manage CROs, and eventually lead a small internal team while collaborating with FDA and other health authorities.