VP, Clinical Operations — Lead End-to-End Trials

Slate Medicines; Raleigh (NC); On-site; USD 250,000 - 350,000; Full time

Job summary

Slate Medicines, a clinical-stage biotechnology company, seeks an experienced Vice President of Clinical Operations to lead end-to-end planning and execution of its clinical studies. This hands-on leadership role defines the operating model, selects external partners, and grows the internal Clinical Operations organization as the program advances.

The VP will own study timelines, budgets, risk mitigation, and vendor performance while partnering with Clinical Development, Regulatory,

Qualifications

• Sponsor-side Clinical Operations experience with leadership responsibilities.
• Experience managing Phase 2/3 studies from start-up to database lock.
• Knowledge of ICH GCP and regulatory requirements in the regions of study.
• Proven CRO selection, contracting, and oversight track record.
• Experience building Clinical Operations capabilities in a lean environment.
• Strong communication and stakeholder alignment across teams.

Responsibilities

• Own Clinical Operations planning and execution for development-stage studies, from start-up to delivery.
• Lead CRO strategy: evaluation, contracting, governance, and ongoing performance management.
• Build infrastructure, processes, and systems suitable for a lean clinical-stage company.
• Develop and manage study timelines, budgets, risk mitigation, and vendor performance.
• Partner with Clinical Development, Regulatory, Biostatistics/Data Management, and other stakeholders.
• Build the internal Clinical Operations team over time, including hiring priorities and responsibilities.
• Operate as a hands-on leader balancing strategy with program execution details.
• Provide clear, timely communication to executive leadership on status, risks, decisions, and resourcing.

Skills

Clinical Operations

Leadership

Vendor Management

GCP/ICH E6

Regulatory Knowledge

Cross-functional Collaboration

Job description

Slate Medicines, a clinical-stage biotechnology company, seeks an experienced Vice President of Clinical Operations to lead end-to-end planning and execution of its clinical studies. This hands-on leadership role defines the operating model, selects external partners, and grows the internal Clinical Operations organization as the program advances.

The VP will own study timelines, budgets, risk mitigation, and vendor performance while partnering with Clinical Development, Regulatory,