Translational Neuroscience Postdoctoral Fellow

McLean Hospital; Belmont (MA); On-site; USD 2,100 - 3,120,000; Full time

Job summary

McLean Hospital invites applications for a postdoctoral fellow in Translational Neuroscience and Psychiatric Disorders. The role focuses on human postmortem brain studies, single-cell transcriptomics, advanced microscopy, and integration with clinical phenotypes using NLP approaches.

The Translational Neuroscience Laboratory at McLean Hospital and Harvard Medical School seeks a highly motivated fellow to investigate cellular mechanisms underlying psychiatric disorders and stress-related

Qualifications

• PhD/MD or equivalent in neuroscience or related field required.
• Experience with postmortem brain research or neuropathology is desirable.
• Strong analytical and publication record.

Responsibilities

• Conduct studies using well-characterized human postmortem brain specimens from donors with psychiatric disorders and unaffected comparison donors.
• Perform advanced fluorescence microscopy, multiplex in situ RNA and protein detection, and quantitative image analysis.
• Investigate cellular morphology, cytoarchitecture, microvascular organization, and structural features of the blood-brain barrier and NVU.
• Establish and study primary human astrocyte, microglial, and brain endothelial cell cultures derived from postmortem brain tissue.
• Conduct experiments using iPSC-derived glial and vascular cell models, including comparisons with primary cells and native brain tissue from the same donors.
• Design experiments examining cellular responses to cytokines, stress neuropeptides, and other immune or metabolic challenges.
• Apply single-cell or single-nucleus transcriptomic approaches to whole brain tissue, isolated microvasculature, and cultured cells.
• Analyze cell-type-specific and coordinated multicellular gene-expression programs involving neurons, astrocytes, microglia, endothelial cells, pericytes, and other NVU components.
• Integrate molecular, cellular, morphological, and functional measures with transdiagnostic dimensions of stress-related symptoms.
• Work collaboratively with investigators ...
• Contribute to experimental design, data analysis and interpretation, manuscript preparation, scientific presentations, and grant applications.
• Develop independent research questions and pursue opportunities for fellowship and career-development funding.

Skills

Fluorescence microscopy

Single-cell RNA sequencing

Cell culture & iPSC

Data analysis

Molecular biology

Neuroscience background

Neuroimmunology

Education

PhD or MD or equivalent doctoral degree in neuroscience or related field

Tools

Confocal microscopy

Multiplex RNA/protein detection

Job description

McLean Hospital invites applications for a postdoctoral fellow in Translational Neuroscience and Psychiatric Disorders. The role focuses on human postmortem brain studies, single-cell transcriptomics, advanced microscopy, and integration with clinical phenotypes using NLP approaches.

The Translational Neuroscience Laboratory at McLean Hospital and Harvard Medical School seeks a highly motivated fellow to investigate cellular mechanisms underlying psychiatric disorders and stress-related