Therapeutic Programs Lead, Early Validation & Impact

Capable; San Francisco (CA); On-site; USD 155,000 - 260,000; Full time

Benefits offered by this job

Wellness budget

Healthcare coverage

401K plan

Visa sponsorship

Team dinners

Job summary

Capable is seeking a driven leader to originate and lead new therapeutic programs from concept through early validation in San Francisco. You will identify ambitious opportunities, define targets, modalities, assays, biomarkers, budgets, timelines, and kill criteria, with up to $1M initial validation funds.

You will collaborate across scientific teams, evaluate literature and data, and own program progress and resource decisions while staying close to experiments.

Qualifications

• Proven track record of originating and advancing scientific or therapeutic programs.
• Ability to turn a promising mechanism or biological opportunity into an executable, falsifiable program.
• High-agency, precise, skeptical, execution-oriented working style balancing speed with rigor.

Responsibilities

• Originate and lead therapeutic programs from concept through early validation.
• Define each program’s target, mechanism, modality, assay strategy, biomarkers, model systems, translational path, budget, timeline, decision points, and kill criteria.
• Execute alongside the scientific team through literature review, experimental design, molecule design or sourcing, assay development, in vitro and in vivo testing, data review, and next-round decisions.
• Build the capabilities around promising programs by identifying collaborators and advisors, selecting partners and models, procuring instruments, and helping assemble teams.
• Own program progress and resource decisions while remaining directly engaged with primary data, failures, and scientific tradeoffs.

Skills

Scientific judgment

Program ownership

Interdisciplinary leadership

Execution oriented

Job description

Capable is seeking a driven leader to originate and lead new therapeutic programs from concept through early validation in San Francisco. You will identify ambitious opportunities, define targets, modalities, assays, biomarkers, budgets, timelines, and kill criteria, with up to $1M initial validation funds.

You will collaborate across scientific teams, evaluate literature and data, and own program progress and resource decisions while staying close to experiments.