Technical Project Manager – Radiopharmaceutical Program

Orchestralifesciences; Madison (WI); Hybrid; USD 80,000 - 110,000; Full time

Benefits offered by this job

Flexible work arrangements

Opportunity to impact cancer therapies

Collaborative culture

Job summary

Orchestra Life Sciences in Madison, WI, seeks a Technical Project Manager to lead complex projects in radiopharmaceutical development. This role involves driving delivery excellence across high-impact capital equipment projects, ensuring timely execution and adherence to regulatory compliance.

With a hybrid work model, the position also requires travel ranging from 25–50% to client sites. The ideal candidate will have over 7 years of project management experience and a solid technical background. Join us to impact the field of cancer treatment.

Qualifications

• 7+ years of project management experience in biotech, pharma, or regulated environments.
• Demonstrated experience managing capital equipment projects.
• Strong understanding of project management fundamentals.

Responsibilities

• Own end-to-end project delivery for capital equipment projects.
• Develop and maintain integrated project schedules.
• Serve as the primary point of contact for project status.

Skills

Project management experience

Strong communication skills

Problem-solving skills

Education

Bachelor’s degree in a technical field

Project management credential

Tools

MS Project

Smartsheet

Job description

Technical Project Manager – Radiopharmaceutical Program

Orchestra Life Sciences is a technical consultancy delivering deep expertise in nuclear medicine development, specializing in Radioligand Therapies (RLTs) and Targeted Alpha Therapies that are transforming cancer treatment. We provide end-to-end capital project solutions that take specialized facilities from feasibility studies through cGMP qualification, with a proven track record of optimizing regulatory compliance, costs, and timelines. Our team of subject matter experts brings more than 100 years of combined experience in novel therapies, working in concert with clients across nuclear medicine, radiation oncology, cell and gene therapies, regenerative medicines, and biotechnology to accelerate life-saving treatments to market.

Position Overview

We are seeking a Technical Project Manager to join our growing Radiopharmaceutical Program team, managing complex, multi-disciplinary projects at the forefront of nuclear medicine. This role offers a unique opportunity to drive delivery excellence across a portfolio of high-impact capital equipment projects—including hot cells, cyclotrons, and large-scale process systems—as well as process scale-up and commercialization initiatives. You will serve as the central coordinator and accountable owner of project execution, working closely with process engineers, mechanical engineers, automation specialists, quality teams, and clients to keep programs on scope, schedule, and budget. Your work will directly enable life-saving cancer therapies to reach patients.

This is a hybrid position offering flexibility to work from home, our Madison office, and client project sites nationwide. Project phases require varying levels of face‑to‑face collaboration for effective delivery. Travel expectations typically range from 25–50%. Travel requirements may increase during critical project phases such as equipment procurement, Factory Acceptance Testing (FAT), commissioning activities, and startup operations. Travel is scheduled during business days to support project delivery; extended travel over weekends to enable consecutive weeks onsite is not typical practice.

Key Responsibilities

Project Planning & Execution:

• Own end-to-end project delivery for capital equipment and process projects, including scope definition, integrated scheduling, resource planning, risk management, and budget tracking
• Develop and maintain project plans, work breakdown structures (WBS), and critical path schedules for multi-disciplinary teams across engineering, procurement, construction, and qualification phases
• Drive accountability across internal team members and external vendors, ensuring milestone commitments are met and issues are escalated with solutions

Capital Equipment & Facility Projects:

• Manage projects for large capital equipment including hot cells, cyclotrons, isolators, containment systems, and process skids from concept through commissioning and handoff
• Coordinate procurement, vendor management, and logistics for specialized radiopharmaceutical equipment, interfacing with hot cell suppliers (e.g., Comecer, Von Gahlen, PBL) and other OEM partners
• Support Factory Acceptance Testing (FAT), Site Acceptance Testing (SAT), and equipment qualification (IQ/OQ/PQ) activities, ensuring execution against approved protocols and documentation requirements
• Interface with facility design teams, architects, construction partners, and client operations teams to ensure equipment and process requirements are aligned with building systems and site readiness

Process Scale‑Up & Commercialization Projects:

• Lead project management for radiopharmaceutical process scale‑up initiatives, from R&D through pilot and commercial manufacturing, coordinating cross-functional workstreams across process engineering, quality, and regulatory teams
• Track and report on critical process parameters, technology transfer milestones, and regulatory submission timelines, ensuring dependencies are visible and risks are proactively managed
• Partner with process engineers to develop project-level plans for process validation, equipment qualification, and operational readiness activities

Stakeholder Communication & Reporting:

• Serve as the primary point of contact for project status, maintaining clear and consistent communication with clients, internal leadership, and project team members
• Produce weekly project health reports with clear status indicators (Green / Yellow / Red), risk registers, and action item logs; ensure no surprise escalations
• Facilitate project meetings, design reviews, and coordination calls, driving clear decisions, documented action items, and accountability
• Support proposal development and project scoping activities by providing realistic schedule and resource estimates grounded in project experience

Required Qualifications

• Bachelor’s degree in a technical field, or equivalent work experience in mechanical engineering, chemical engineering, project engineering, or a related discipline
• 7+ years of project management experience on complex, multi-disciplinary technical projects in biotech, pharma, life sciences, nuclear, or regulated manufacturing environments
• Demonstrated experience managing capital equipment projects, including vendor coordination, procurement, and installation oversight
• Strong understanding of project management fundamentals: scope management, scheduling (critical path), risk management, budget tracking, and change control
• Experience developing and maintaining integrated project schedules using tools such as MS Project, Smartsheet, or equivalent
• Excellent communication and stakeholder management skills, with ability to translate technical complexity into clear updates for diverse audiences
• Comfortable working in a fast-paced, matrixed consulting environment across multiple active projects simultaneously

Preferred Qualifications

• Mechanical engineering background or project engineering experience in equipment design, procurement, or installation
• Familiarity with GMP requirements, FDA regulations (21 CFR Parts 210/211), and pharmaceutical quality systems
• Exposure to radiopharmaceutical manufacturing, hot cell operations, or nuclear medicine production environments
• Experience on new facility construction or new production line startup projects
• Knowledge of equipment qualification activities (IQ/OQ/PQ, FAT/SAT) and associated documentation requirements
• PMP certification or equivalent project management credential
• Experience working in a consulting or client-facing technical services environment

Why Join Orchestra?

• Help build the infrastructure for next‑generation cancer therapies that are transforming oncology treatmentIndustry Impact:
• Manage projects spanning capital equipment, process development, facility integration, and commercial scale‑up across multiple clients and therapeutic modalitiesTechnical Variety:
• Serve as the accountable leader for project delivery—your decisions and discipline directly shape client outcomesMeaningful Ownership:
• Work alongside industry-leading engineers, scientists, and consultants in a knowledge‑sharing, high‑trust environmentCollaborative Culture:
• Gain deep exposure to the emerging radiopharmaceutical sector at a company shaping the standards of the fieldProfessional Growth:
• Madison office with flexible arrangements; travel to client sites as neededLocation:

Orchestra Life Sciences is an equal opportunity employer committed to building a diverse and inclusive team.