Technical Project Manager

Illumina; San Francisco (CA); On-site; USD 103,000 - 155,000; Full time

Job summary

Illumina, a leader in genomic technology, is seeking a Technical Project Manager to drive the execution of cross-functional projects across sustaining engineering, lifecycle management, manufacturing, supply chain, quality, and operations within Instrument Operations.

You will plan, coordinate, and monitor plans, budgets, risks, and milestones, partner with engineering, manufacturing, quality, and regulatory teams, and communicate progress to leadership in a fast-paced environment.

Qualifications

• Bachelor's degree in Engineering, Science, Operations, Manufacturing, or a related technical discipline.
• Experience leading technical, engineering, operational, manufacturing, or product-related projects.
• Working knowledge of project management methodologies and tools, including project planning, schedule management, risk management, and status reporting.
• Strong analytical and problem-solving skills, with the ability to synthesize information from multiple sources into actionable recommendations.
• Effective written, verbal, presentation, and stakeholder management skills.
• Ability to manage multiple priorities, work independently, and maintain attention to detail in a dynamic environment.
• Demonstrated ability to influence and coordinate cross-functional teams without direct authority.

Responsibilities

• Own and drive cross-functional technical projects from initiation through implementation and closure.
• Develop and maintain project plans, schedules, resource forecasts, budgets, risk registers, and mitigation plans.
• Facilitate project meetings, technical reviews, engineering reviews, and stakeholder updates.
• Coordinate execution across engineering, manufacturing, quality, supply chain, service, regulatory, and other functional teams.
• Monitor project performance against scope, schedule, budget, quality, and success criteria.
• Identify risks, issues, and dependencies, and drive timely resolution and escalation when needed.
• Support engineering change orders (ECOs), product lifecycle management activities, sustaining engineering initiatives, new product introductions (NPI), cost reduction efforts, supply continuity programs, and end-of-life initiatives.
• Track and communicate milestones, decisions, action items, and project status to stakeholders and leadership.
• Maintain project documentation in accordance with applicable quality and regulatory requirements.
• Develop dashboards, metrics, and portfolio reporting to support governance and data-driven decision-making.
• Drive continuous improvement to strengthen project delivery, operational efficiency, business processes, and product quality.

Skills

Project management

Cross-functional coordination

Analytical thinking

Stakeholder management

Communication

Education

Bachelor's degree in Engineering, Science, Operations, Manufacturing, or related technical discipline

Tools

Microsoft Project

Jira

Planisware

Smartsheet

Asana

Job description

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Illumina is seeking a Technical Project Manager to drive the execution of technical projects across a portfolio of sustaining engineering, lifecycle management, manufacturing, supply chain, quality, and operations initiatives within Instrument Operations. The successful candidate will partner with cross-functional teams to plan, coordinate, and execute projects while balancing scope, schedule, resources, quality, and business objectives.

This individual must be comfortable working in a fast-paced technical environment, managing multiple projects simultaneously, and communicating effectively across all levels of the organization.

Responsibilities:

• Own and drive cross-functional technical projects from initiation through implementation and closure.
• Develop and maintain project plans, schedules, resource forecasts, budgets, risk registers, and mitigation plans.
• Facilitate project meetings, technical reviews, engineering reviews, and stakeholder updates.
• Coordinate execution across engineering, manufacturing, quality, supply chain, service, regulatory, and other functional teams.
• Monitor project performance against scope, schedule, budget, quality, and success criteria.
• Identify risks, issues, and dependencies, and drive timely resolution and escalation when needed.
• Support engineering change orders (ECOs), product lifecycle management activities, sustaining engineering initiatives, new product introductions (NPI), cost reduction efforts, supply continuity programs, and end-of-life initiatives.
• Track and communicate milestones, decisions, action items, and project status to stakeholders and leadership.
• Maintain project documentation in accordance with applicable quality and regulatory requirements.
• Develop dashboards, metrics, and portfolio reporting to support governance and data-driven decision-making.
• Drive continuous improvement to strengthen project delivery, operational efficiency, business processes, and product quality.

Required Qualifications:

• Bachelor's degree in Engineering, Science, Operations, Manufacturing, or a related technical discipline.
• Experience leading technical, engineering, operational, manufacturing, or product-related projects.
• Working knowledge of project management methodologies and tools, including project planning, schedule management, risk management, and status reporting.
• Strong analytical and problem-solving skills, with the ability to synthesize information from multiple sources into actionable recommendations.
• Effective written, verbal, presentation, and stakeholder management skills.
• Ability to manage multiple priorities, work independently, and maintain attention to detail in a dynamic environment.
• Demonstrated ability to influence and coordinate cross-functional teams without direct authority.

Preferred Qualifications:

• Experience in life sciences, biotechnology, medical devices, diagnostics, or another regulated industry.
• Familiarity with product lifecycle management (PLM), engineering change control, design controls, or quality systems.
• Experience with project management tools such as Microsoft Project, Jira, Planisware, Smartsheet, Asana, or equivalent platforms.
• Knowledge of Lean Six Sigma, Agile, Hybrid, Kanban, or Scrum methodologies.
• PMP, PMI-ACP, Lean Six Sigma, or similar professional certification.

Additional Information

All listed requirements are deemed essential functions of this position. Business conditions may require reasonable accommodation for additional tasks and responsibilities.

The estimated base salary range for the Technical Project Manager role based in the United States of America is: $103,000 - $154,600. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long‑term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement bene