Technical Operations Manager, GMP Engineering and Cell Manufacturing Facility

Roswell Park Comprehensive Cancer Center; Buffalo (NY); On-site; USD 111,000 - 136,000; Full time

Job summary

Roswell Park Comprehensive Cancer Center in Buffalo, NY seeks a Technical Operations Manager to lead CAR-T and other cell therapy manufacturing within a GMP facility. You will oversee day-to-day operations, coordinate development activities, and ensure compliance with cGMP and safety standards while optimizing productivity and profitability.

The role requires advanced degree in health/ science and significant GMP manufacturing experience; preferred lean, agile delivery, and CDMO exposure.

Qualifications

• PhD with 3 years GMP manufacturing experience or Master’s with 5 years GMP manufacturing experience.
• Degrees must be conferred by an accredited institution or equivalent per Roswell Park/HRI standards.

Responsibilities

• Lead a team responsible for manufacturing CAR-T and other cell therapies within the GMP Engineering & Cell Manufacturing Facility.
• Oversee day-to-day operations of cell therapy programs, including manufacturing, facilities cleaning and maintenance.
• Coordinate process and analytical development activities and ensure compliance with cGMP and safety protocols.
• Partner with departments to optimize production processes and implement innovative productivity improvements.
• Assist Technical Operations management with budgets, statements of work, and reporting documents.

Skills

Scrum Master

Agile delivery

Lean Six Sigma

CDMO experience

Quality systems awareness

Education

PhD in health or science related field

Master's degree in health or science related field

Tools

TrackWise

MasterControl

Job description

Title: Technical Operations Manager, GMP Engineering & Cell Manufacturing Facility

Job Type: Regular

Company: Health Research, Inc. (HRI) Roswell Park Division

Department: Center for Immunotherapy

Time Type: Full time

Weekly Hours: 40

FTE: 1

Shift: First Shift (United States of America)

Summary:

Leads a team of professional associates responsible for the manufacturing of CAR‑T and other cell therapies within the GMP Engineering & Cell Manufacturing Facility. Oversees the day‑to‑day operations of cell therapy programs, including manufacturing and facilities cleaning and maintenance. Coordinates process and analytical development activities, ensuring compliance with cGMP (Good Manufacturing Practice) regulatory standards and safety protocols as well as managing the company’s resources effectively. Ensures efficient production processes and effective analytical strategies and methods, coordinating with different departments, and implementing innovative approaches to improve productivity and profitability. Works closely with the team to provide process, material, and equipment knowledge to meet customer requirements and addresses operational and routine challenges as they arise for manufacturing. Participates and assists Technical Operations management with the preparation of budgets, statements of work, and other documents requested by internal and external customers required for reporting purposes, oversight of operations and for publication.

The salary range for this position is $111,387 - $135,829 annually which includes a comprehensive benefits package. The actual offer may vary based on qualifications, skills, and experience.

Qualifications:

• Required Education and Experience 1. PhD in a health or science related field and the equivalent of three (3) years of full‑time experience in GMP Manufacturing; or 2. Master's degree in a health or science related field and the equivalent of five (5) years of full‑time experience in GMP Manufacturing.
• NOTE: Degrees must be conferred by an accredited school, college, or university, or by an institution recognized by Roswell Park Comprehensive Cancer Center and/or Health Research Incorporated as adhering to acceptable educational standards.

Preferred Qualifications:

• The preferred candidate will have: Certified Scrum Master / Agile delivery experience (helpful for systems implementations and cross‑functional execution)
• Lean Six Sigma Black Belt (or equivalent demonstrated CI leadership)
• CDMO experience, including client‑facing delivery, tech transfer, and rapid timeline execution
• Experience with common quality/systems tools (e.g., TrackWise / MasterControl / similar)

Equal Employment Opportunity Statement

Roswell Park Cancer Institute Corporation (RPCIC) and Health Research Inc. (HRI) Roswell Park Division believe that all persons are entitled to equal employment opportunities, and we do not discriminate against our employees, applicants or job seekers because of their race, color, religion, sex, sexual orientation, gender identity or expression, national origin, creed, age, disability, pregnancy‑related condition, military or veteran status, marital or familial status, domestic violence victim status, citizenship status, genetic information, individual's relationship or association with a member of a protected category or any other protected group status as defined by law.

Affirmative Action/Equal Opportunity Employer/Qualified Individuals with Disabilities/Qualified Protected Veterans Reasonable Accommodation Request RPCIC and HRI are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email [e-mail] and let us know the nature of your request and your contact information.

Our Core Values

RPCIC and HRI are committed to providing an environment where patients, families, employees and community are treated with courtesy and respect. We support an inclusive environment that nurtures the talents, skills and abilities of each individual to embody and reflect our core values: Innovation, Integrity, Teamwork, Commitment, Compassion and Respect.

Grant Funding

This is a grant‑funded position. Compliance with funding requirements such as time and effort reporting, grant deliverables, and contract deliverables is required.

E‑Verify

Employer Health Research Inc. (HRI) Roswell Park Division participates in the E‑Verify program.

Welcome

Welcome to Roswell Park Comprehensive Cancer Center, America's first cancer center founded in 1898 by Dr. Roswell Park. As one of the largest employers in Western New York, Roswell has over 3,300 employees, including over 200 physicians and scientists and 400 nurses. It’s a new era at Roswell Park. Leading the way in cancer research, treatment and education for more than a century, today Roswell Park is setting our course for a second century of extraordinary advances in cancer research and treatment. Equipped with the best facilities, the sharpest and most creative minds, and the single objective of curing cancer, we stand on the threshold of historic discovery.