TDS Proteins Cell Line Engineering Co-Op

Biopharma Careers; Pennsylvania; On-site; USD 42,000 - 62,000; Full time

Job summary

Johnson & Johnson is seeking a TDS Proteins Cell Line Engineering Co-Op in Spring House, PA. The six-month, on-site program runs January–June 2027, supporting cell line engineering and research in a collaborative, cross-functional environment.

You will gain hands-on experience with mammalian cell culture, molecular biology, and data analysis, contributing to improved protein expression and secretion. The role emphasizes teamwork, documentation, and scientific communication.

Qualifications

• Completion of Undergraduate Freshman year at an accredited University is required.
• GPA 3.0 or higher across coursework.
• No conflicting Summer Internship commitments that interfere with the specified dates.

Responsibilities

• Investigate stress and secretory pathways in CHO cells to identify bottlenecks.
• Support cell line engineering to improve protein production, folding, and secretion.
• Collaborate with proteomics and cross-functional teams to validate targets.
• Conduct aseptic lab work and molecular biology experiments.
• Analyze data using statistical approaches and communicate results.
• Participate in design discussions and problem-solving with the team.
• Maintain accurate notebooks and document procedures per guidelines.

Skills

Cell culture

Aseptic technique

Data analysis

Molecular biology

RT-qPCR

Western blot

Digital PCR

Flow cytometry

Education

Undergraduate freshman year

Tools

Western blot equipment

PCR instruments

Flow cytometer

Job description

Johnson & JohnsonPosted October 9, 2026# TDS Proteins Cell Line Engineering Co-OpSpring House, United States Full timeDrug Discovery & Preclinical Research Intern/Fellow/PostdocNotify me about similar jobsView Full Job & Apply at Johnson & JohnsonJohnson & Johnson is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.## About this opportunityAt Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com .As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.**Job Function:**Career Programs**Job Sub Function:**Non-LDP Intern/Co-Op**Job Category:**Career Program**All Job Posting Locations:**Spring House, Pennsylvania, United States of America**Job Description:****About Innovative Medicine**Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicineWe are searching for the best talent for **TDS Proteins Cell Line Engineering Co-Op** to be in **Spring House, PA.**1 vacancy is currently available.TheCo-op term is six months typically from **January to June, 2027** (flexible).Full time requirement (40 hours per week) Fully On-site.**Purpose:**The TDS Proteins Development Cell Engineering, Analytics & Screening (CEAS) organization is seeking a highly motivated Co-Op to support cell line engineering and research activities focused on improving biotherapeutic protein expression and cell culture performance.In this role, the Co-Op will investigate cellular stress and secretory pathways in CHO cell systems to identify potential expression bottlenecks and support the evaluation of novel targets associated with protein production, folding, and secretion. This opportunity provides hands-on experience in mammalian cell culture, molecular biology techniques, experimental design, and data analysis while collaborating with multidisciplinary scientific teams.**You will be responsible:**Investigating stress and secretory pathways in engineered and wild-type CHO cell hosts to identify potential bottlenecks affecting protein expression.Supporting cell line engineering studies aimed at improving protein production, folding, and secretion.Collaborating with proteomics and other cross-functional scientific teams to evaluate and validate novel cell engineering targets.Conducting laboratory experiments using aseptic cell culture and molecular biology techniques.Supporting experimental characterization using techniques such as Western blot analysis, RT-qPCR, digital PCR, and flow cytometry, as applicable.Analyzing and interpreting experimental results using analytical and statistical approaches.Participating in experimental design discussions and technical problem-solving to address knowledge gaps and advance research objectives.Communicating experimental findings and actively participating in meetings with internal and external collaborators.Maintaining accurate laboratory notebooks and technical documentation in accordance with established guidelines.Providing additional laboratory and project support as needed.**Qualifications / Requirements:**Completion of Undergraduate Freshman year at an accredited University is required.Currently pursuing a Bachelor’s, Master’s or PhD degree in Biology, Chemistry, Analytical Chemistry, Biochemistry, Molecular Biology, Microbiology, Chemical Engineering, Biological Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a related scientific or engineering discipline.Have a cumulative GPA of 3.0 or higher, which is reflective of all college coursework.You must not have any Summer Internship contract or other employment commitment that could interfere with the contract dates specified for this position.Previous hands-on experience with aseptic cell culture is required.Strong analytical, quantitative, and problem-solving skills.Ability to analyze and interpret experimental data and communicate scientific conclusions.Ability to work independently as a self-starter while contributing effectively to collaborative team goals.Ability to manage multiple responsibilities and priorities.Candidates must be legally authorized to work in the U.S. and must not require sponsorship for employment visa status now or in the future.Permanently authorized to work in the U.S., must not require sponsorship of an employment visa (e.g., H-1B or green card) at the time of application or in the future. Students currently on CPT, OPT, or STEM OPT usually requires future sponsorship for long term employment and do not meet the requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship.If you are under 18 years of age, you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check.Preferred Qualifications:Hands-on experience with Western blot analysis, RT-qPCR, and/or digital PCR.Knowledge of or exposure to flow cytometry is a plus.Familiarity with CHO cells, mammalian cell culture, cell line engineering, or cell line development.Basic laboratory skills and previous experience in biological or biopharmaceutical research.Experience with experimental design, execution, and data analysis.Understanding of molecular and cellular biology concepts related to protein expression, folding, secretion, or cellular stress pathways.Strong communication and presentation skills.Demonstrated leadership through academic projects, campus organizations, research activities, or community involvement.Ineligibility for severance.Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.**#LI-Onsite****#TDSCo-OpSpring2027****Required Skills:****Preferred Skills:**