Supervisor, Manufacturing Operations (Second Shift)

Vertex Pharmaceuticals Inc (US); United States; On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

Paid time off

Educational assistance

Commuting subsidy

401(k)

Job summary

Vertex is seeking a Manufacturing Operations Supervisor to lead a 2-8 person cell manufacturing team on GMP processes for adherent and suspension cultures. The role focuses on coaching, training, and ensuring cGMP compliance across operations and quality systems.

The incumbent will manage shift-based production, coordinate with cross-functional partners, and drive continuous improvement through SOPs, batch records, and equipment troubleshooting in a cleanroom environment.

Qualifications

• GMP experience, including lead or trainer roles.
• Minimum of 3 years cell culture experience in adherent and suspension cultures.
• 0-2 years direct supervisory experience.
• Working knowledge of federal GMP manufacturing requirements (21CFR 210,211) and Quality Systems (21CFR 820).
• Expertise in cell processing and culture technologies for clinical materials production.
• Experience with bioreactors for cell culture.
• Proficient with Word, Excel, Project, Outlook and electronic quality systems.

Responsibilities

• Builds and develops a 2-8 direct report team for clinical product or intermediates per cGMP standards.
• Hire, orient, train and coach personnel; oversee scheduling with other Manufacturing leadership.
• Ensure cGMP compliance through education and oversight of team members.
• Lead project management for direct reports, including timelines and meetings.
• Collaborate with cross-functional stakeholders on quality systems, CAPAs, change controls, and risk assessments.
• Create, revise and review SOPs and Batch Records for manufacturing.

Skills

GMP experience

Cell culture

Supervisory experience

Leadership

cGMP

Bioreactors

Quality systems

Computer skills

Tools

Word

Excel

Project

Outlook

Equipment interfaces

Electronic quality systems

Job description

Job Description Job Description The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients. The Supervisor will work one of the following shifts: Second Shift - Tuesday to Saturday, 2:30PM - 11PM Second Shift - Sunday to Thursday, 2:30PM - 11PM

Key Duties and Responsibilities:

Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel. Ensures cGMP compliance through direct oversight and education of team members. Shares responsibility of scheduling of personnel in coordination with other Manufacturing leadership. Manages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings. Leads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments. Creates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing. Receive and manage equipment alarms. Serves as a technical SME for the team, troubleshoots problems independently. Demonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking Other duties and projects as assign as required to meet departmental requirements.

Knowledge and Skills:

Extensive GMP experience, including as a lead or trainer. Minimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures. A minimum of 0-2 years direct supervisory experience. Working knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820). Expertise in cell processing and culture technologies for clinical materials production required. Experience with bioreactors for cell culture. Excellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems.

Environment:

Works in a cleanroom and office setting. Must be able to remain in a stationary position 50% during processing activities. Frequently move about inside the cleanroom to accomplish process tasks. Occasionally moves lab equipment and materials weighing up to 50 pounds.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

• From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• educational assistance programs including student loan repayment
• a generous commuting subsidy
• matching charitable donations
• 401(k)
• and so much more

Flex Designation:

On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.