Supervisor, Manufacturing Operations 3rd shift (3B)

Vertex Pharmaceuticals Inc (US); United States; On-site; USD 98,000 - 147,000; Full time

Benefits offered by this job

Medical, dental, vision

Paid time off

Educational assistance

Commuting subsidy

401(k)

Job summary

Vertex Pharmaceuticals Inc is seeking a Supervisor, Manufacturing Operations to lead overnight and shift manufacturing activities. You will assign work based on schedules and plans, oversee cGMP operations including equipment setup, and ensure accurate documentation through batch records.

The role requires a Bachelor’s degree in a science/engineering field with 6+ years’ experience or equivalent, plus supervisory experience and familiarity with aseptic manufacturing and MES systems.

Qualifications

• Bachelor’s degree in a scientific, technical or engineering discipline with 6+ years of experience or equivalent combination.
• Prior supervisory or leadership experience preferred.
• Prior cell therapy and aseptic manufacturing experience preferred.

Responsibilities

• Lead and supervise daily manufacturing operations.
• Assign work to shift personnel based on production schedules and plans.
• Oversee cGMP manufacturing activities including equipment setup, operation, disassembly and cleaning.
• Execute and witness batch record instructions to ensure compliant docs.
• Perform real-time batch record review on the floor.
• Interface with cross-functional teams to support facility operations and maintenance.
• Monitor GMP compliance for personnel and activities in the Drug Product facility.
• Maintain audit-ready facility by following procedures and documentation standards.
• Lead and participate in Tier 0 and Tier 1 meetings.

Skills

Leadership

People management

cGMP knowledge

SOP adherence

Communication

Project management

Education

Bachelor’s degree in science/engineering

Tools

POMS MES

Job description

Job Description General Summary: The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities.

Key Duties and Responsibilities:

• Lead and supervise daily manufacturing operations.
• Assign work to shift personnel based on detailed production schedules and operational plans.
• Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning.
• Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation.
• Performs real-time on the floor batch record review.
• Interface with cross-functional teams to support facility operations, maintenance activities, and manufacturing objectives.
• Monitor and enforce GMP compliance for all personnel and activities within the Drug Product facility.
• Maintain the facility in an audit-ready state through adherence to procedures, documentation standards, and inspection readiness practices.
• Ensure compliance with SOPs, policies, and work instructions to support safe and successful facility operation.
• Work with QA Document Control to request, receive, and return MBRs for process operations.
• Demonstrate the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking.
• Maintain personal and team compliance with all ongoing training requirements.
• Leading and Attending Teir 0 and Tier 1 meetings.
• Perform other duties and projects as assigned to meet departmental requirements.

Knowledge and Skills:

• Demonstrates leadership behaviors, including supporting team development, serving as a technical lead during triage activities, and recognizing team contributions.
• Leads, develops, and coaches direct reports.
• Effective interpersonal, verbal, and written communication skills, with the ability to work in a dynamic team environment.
• Strong organizational skills with the ability to manage priorities and maintain timelines across multiple projects.
• Sound understanding relevant drug development activities and standard operating procedures (SOPs_. Ability to clearly explain why procedures, practices, or technical approaches are being used.
• Solid understanding of the cGMP framework in both development and commercial pharmaceutical drug product manufacturing environments.
• Must be able to remain in a stationary position up to 50% of the time during processing activities.
• Must be able to frequently move about within the cleanroom to perform process tasks.
• Must be able to occasionally move lab equipment and materials weighing up to 50 pounds.
• Work is performed in a manufacturing environment where compressed gases and liquid nitrogen (LN2) are used as part of process requirements.
• Occasional availability to work other shifts may be necessary for onboarding and training.

Education and Experience:

Bachelor’s degree in a scientific, technical or engineering discipline 6+ years of experience or the equivalent combination of education and experience Prior supervisory or leadership experience preferred Prior cell therapy and aseptic manufacturing experience preferred Prior POMS MES experience preferred.

Work Schedule:

This position supports our overnight operations and follows the following schedules: Wednesday through Saturday, 9:00 PM to 7:30 AM

Training Period:

New hires will complete an approximately 90-day onboarding and training program on either first shift or second shift before transitioning to the assigned overnight schedule.

Training will take place between our Cambridge Facility: 100 Tech Drive and Leiden Center 1 (LC1)

Additional Schedule Information:

Please note that work schedules are based on business needs and may be adjusted or modified as operational requirements evolve. Candidates must be flexible and able to accommodate schedule changes, including shifts, assigned days or hours, as determined by Vertex at Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Flex Designation:

On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East.

Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For.

For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work.

The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

Pay Range:

$97,900 - $146,900

Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

• From medical, dental and vision benefits
• Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• Educational assistance programs including student loan repayment
• Generous commuting subsidy
• Matching charitable donations
• 401(k)
• and so much more