Supervisor, Manufacturing Operations 2nd shift (2B)

Vertex Pharmaceuticals Inc (US)

United States

On-site

USD 98,000 - 147,000

Full time

2 days ago

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Benefits offered by this job

Medical benefits

Dental benefits

Paid time off

Job summary

Vertex Pharmaceuticals Inc is seeking a Supervisor, Manufacturing Operations to lead first, second, or third‑shift manufacturing activities. You will assign work, oversee cGMP operations, and ensure compliant, efficient execution of production plans at the Cambridge/Leiden sites.

The role includes real-time batch record reviews, cross‑functional collaboration, and maintaining audit readiness while leading a team through a fast‑paced manufacturing environment.

Qualifications

Bachelor’s degree in a scientific, technical or engineering discipline.
6+ years of experience or equivalent combination of education and experience.
Prior supervisory or leadership experience preferred.

Responsibilities

Lead and supervise daily manufacturing operations.
Assign work to shift personnel based on detailed production schedules and plans.
Oversee cGMP manufacturing activities including equipment setup, assembly, operation, disassembly, and cleaning.
Execute and witness batch record instructions during cGMP operations.
Perform real-time on-the-floor batch record review.
Interface with cross-functional teams to support facility operations and manufacturing objectives.
Monitor and enforce GMP compliance for all personnel and activities.
Maintain audit-ready facility through documentation standards and procedures.

Skills

Leadership

Shift supervision

cGMP knowledge

Batch records

Cross-functional collaboration

Education

Bachelor’s degree in scientific/engineering discipline

Tools

POMS MES

Job description

Job Description General Summary:

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities.

Key Duties and Responsibilities:

Lead and supervise daily manufacturing operations.
Assign work to shift personnel based on detailed production schedules and operational plans.
Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning.
Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation.
Performs real-time on the floor batch record review.
Interface with cross-functional teams to support facility operations, maintenance activities, and manufacturing objectives.
Monitor and enforce GMP compliance for all personnel and activities within the Drug Product facility.
Maintain the facility in an audit-ready state through adherence to procedures, documentation standards, and inspection readiness practices.
Ensure compliance with SOPs, policies, and work instructions to support safe and successful facility operation.
Work with QA Document Control to request, receive, and return MBRs for process operations.
Demonstrate the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking.
Maintain personal and team compliance with all ongoing training requirements.
Leading and Attending Teir 0 and Tier 1 meetings.
Perform other duties and projects as assigned to meet departmental requirements.

Knowledge and Skills:

Demonstrates leadership behaviors, including supporting team development, serving as a technical lead during triage activities, and recognizing team contributions.
Leads, develops, and coaches direct reports.
Effective interpersonal, verbal, and written communication skills, with the ability to work in a dynamic team environment.
Strong organizational skills with the ability to manage priorities and maintain timelines across multiple projects.
Sound understanding relevant drug development activities and standard operating procedures (SOPs_. Ability to clearly explain why procedures, practices, or technical approaches are being used.
Solid understanding of the cGMP framework in both development and commercial pharmaceutical drug product manufacturing environments.
Must be able to remain in a stationary position up to 50% of the time during processing activities.
Must be able to frequently move about within the cleanroom to perform process tasks.
Must be able to occasionally move lab equipment and materials weighing up to 50 pounds.
Work is performed in a manufacturing environment where compressed gases and liquid nitrogen (LN2) are used as part of process requirements.
Occasional availability to work other shifts may be necessary for onboarding and training.

Education and Experience:

Bachelor’s degree in a scientific, technical or engineering discipline 6+ years of experience or the equivalent combination of education and experience Prior supervisory or leadership experience preferred Prior cell therapy and aseptic manufacturing experience preferred Prior POMS MES experience preferred

Work Schedule:

This position follows the following afternoon/evening schedule: Tuesday through Saturday, 2:30 PM to 11:00 PM

Training Period:

New hires will complete an approximately 90-day onboarding and training program on their assigned shift schedule to ensure successful integration into the role. Training will take place between our Cambridge Facility: 100 Tech Drive and Leiden Center 1 (LC1)

Additional Schedule Information:

Please note that work schedules are based on business needs and may be adjusted or modified as operational requirements evolve. Candidates must be flexible and able to accommodate schedule changes, including shifts, assigned days or hours, as determined by Vertex.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$97,900 - $146,900

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Total Rewards Offerings:

From medical, dental and vision benefits
generous paid time off (including a week-long company shutdown in the Summer and the Winter)
educational assistance programs including student loan repayment
a generous commuting subsidy
matching charitable donations
401(k)
and so much more

Flex Designation:

On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.