Study Physician- Neuroinflammation, Immunology Cell Therapy

AstraZeneca; Kendall Square (MA); On-site; USD 250,000 - 375,000; Full time

Benefits offered by this job

Short-term incentive

Equity-based awards

Sales commissions

Retirement plans

Paid time off

Health coverage

Job summary

AstraZeneca plc in Cambridge, MA seeks a Study Physician to lead a first-of-its-kind CAR-T cell therapy study for multiple sclerosis, serving as the medical authority for a global program and shaping how novel immune therapies are delivered and assessed.

Based at our Kendall Square site, you will collaborate with clinical scientists and cross-functional experts to advance patient safety and data-driven progress.

Qualifications

• MD or equivalent with neurology board certification and MS experience.
• Experience designing or delivering clinical studies.
• Knowledge of MS trial methodology, endpoints and regulatory requirements.

Responsibilities

• Lead medical design, delivery and interpretation of a multi-cohort MS CAR-T study in accordance with GCP.
• Monitor patient safety across global sites from eligibility to long-term follow-up.
• Assess adverse events and guide dose-escalation decisions within delegated authority.
• Review data for safety, efficacy, biomarkers and decisions to adapt the study.

Skills

Neurology board cert

Clinical research

MS trial endpoints

GCP knowledge

Cross-functional collaboration

Education

MD or MD-equivalent

Job description

Introduction to role:

Are you a neurologist ready to lead a first-of-its-kind CAR-T cell therapy study that could redefine care for people living with multiple sclerosis? In this Study Physician role, you will serve as the study-level medical authority for a global, multi-cohort program in relapsing and progressive MS, directly shaping how novel immune therapies are delivered and assessed. Based at our state-of-the-art Kendall Square site in Cambridge, MA, you will work at the center of a world-leading life sciences ecosystem with direct access to collaborators, technology and patients.

You will partner closely with clinical scientists and cross-functional experts to keep patient safety at the forefront while driving decisive, data-led progress. Do you want to influence dose-escalation decisions, guide benefit-risk assessments and engage top MS investigators to accelerate a therapy that could change the trajectory of disease?

Accountabilities:

• Medical Leadership and Study Design: Own the medical design, delivery and interpretation of a multi-cohort CAR-T study in MS, ensuring integrity, compliance with GCP and fast, well-reasoned decisions that move the program forward.
• Medical Monitoring Across the Patient Journey: Serve as medical monitor from eligibility review through apheresis, infusion and long-term follow-up, ensuring patient safety and clinical consistency across global sites.
• Safety Assessment and Governance: Lead assessment of adverse events, including CRS, ICANS, cytopenias and infections; guide dose-escalation, dose-hold and stopping-rule decisions within delegated authority; and represent the study at safety committees and internal governance.
• Data Synthesis and Decision-Making: Continuously review safety, efficacy, biomarkers and data-quality trends to detect signals early, shape study adaptations and ensure robust, decision-ready data.
• Clinical Adjudication: Adjudicate complex MS events, including relapse and disability progression, to secure consistent, high-quality endpoints.
• Scientific Documents and Results: Provide final medical review of protocols, amendments, ICFs, IB, SAPs and CSRs; lead medical interpretation of results; and contribute to clear, compelling regulatory documentation.
• External Engagement and Influence: Build strong relationships with investigators and MS experts; support investigator meetings; and contribute to regulatory interactions to align stakeholders around study priorities.
• Cross-Functional Strategy: Bring MS expertise to clinical pharmacology, translational medicine, regulatory, biostatistics, safety and CMC partners to integrate science, operations and strategy.
• Matrix Leadership and Mentorship: Lead through influence, elevate risks transparently and mentor colleagues to raise the bar on medical quality and delivery.
• Portfolio Contribution: Provide medical input to additional neuroimmunology indications and studies as the pipeline evolves, ensuring learnings scale beyond a single program.

Essential Skills/Experience:

• MD or equivalent (PhD a plus), with board certification in neurology and substantive clinical experience in multiple sclerosis.
• Clinical research experience, including hands-on involvement in the design or delivery of clinical studies.
• Sound knowledge of MS trial methodology and endpoints (EDSS, relapses, MRI), biostatistics principles, and FDA, EMA and ICH GCP requirements.
• Ability to influence across a matrix and communicate complex decisions clearly, with a track record of delivering results.

Desirable Skills/Experience:

• Biotech or pharmaceutical clinical-development experience, including oversight of industry-sponsored studies (strongly preferred).
• Experience with CAR-T, other cell therapies or B-cell-depleting therapies in MS or other autoimmune diseases.
• Experience in early-phase or first-in-human studies, including dose escalation.
• Ability to travel nationally and internationally.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from 249,827.20 - 374,740.80 USD Annual [80% - 120% ]. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Why AstraZeneca:

Here, science leads. You will join a culture that pairs deep biology with data, dig