Strategic Immunology Program Leader

Monte Rosa Therapeutics; Boston (MA); On-site; USD 150,000 - 225,000; Full time

Job summary

Monte Rosa Therapeutics seeks a Director/Sr Director of Program Management to guide full life cycle IND to Phase II/III development for immunology/inflammation assets. You will partner with Clinical, Regulatory, CMC, Translational Sciences, and Commercial leaders to align strategy with execution across development stages.

The role requires 12+ years in biotech/pharma, strong cross-functional leadership, and a hands-on, agile approach to navigate regulatory challenges while balancing scientific

Qualifications

• 12+ years of experience in biotechnology or pharmaceutical drug development.
• Minimum 8 years of program/project management experience leading cross-functional development teams.
• Experience advancing immunology and/or inflammation assets through Phase 2 and Phase 3 development.
• Experience preparing for and supporting major regulatory interactions (e.g., End-of-Phase 2 meetings, NDA/BLA submissions).
• Experience operating in small-to-mid-sized biotech environments where agility and hands-on leadership are required.

Responsibilities

• Serve as strategic and operational lead for one or more immunology/inflammation programs, ensuring alignment between clinical strategy, translational insights, and regulatory pathways.
• Develop and maintain integrated development plans across clinical, regulatory, CMC, manufacturing, and translational functions.
• Lead scenario planning to evaluate alternative development pathways and capital-efficient trade-offs.
• Pressure-test timelines and critical paths to streamline execution without compromising quality.
• Establish risk identification and mitigation frameworks for immunology/inflammation programs.

Skills

Program management

Cross-functional leadership

Immunology & inflammation

Strategic planning

Regulatory interactions

Education

BS degree

MS/PhD/MBA preferred

Tools

Smartsheet

MS Project

Teams

Job description

Monte Rosa Therapeutics seeks a Director/Sr Director of Program Management to guide full life cycle IND to Phase II/III development for immunology/inflammation assets. You will partner with Clinical, Regulatory, CMC, Translational Sciences, and Commercial leaders to align strategy with execution across development stages.

The role requires 12+ years in biotech/pharma, strong cross-functional leadership, and a hands-on, agile approach to navigate regulatory challenges while balancing scientific