Staff Software Engineer, Full-Stack

Faeth Therapeutics Inc.; United States; Remote; USD 21,000 - 29,000; Full time

Job summary

Faeth Therapeutics, a clinical-stage oncology company, seeks a Staff Software Engineer to shape core platform architecture and drive secure, high-performance growth. You will work in a small remote team, with broad responsibilities across the stack and a bias for ownership.

You will write production code in React, TypeScript, Node.js/NestJS, and PostgreSQL on AWS, and lead architecture decisions, security, and performance improvements while mentoring others and embracing AI-assisted tooling.

Qualifications

• 8+ years of professional software engineering experience in web apps at scale.
• Experience in high-ambiguity environments with shifting priorities.
• Deep proficiency in modern web stacks (React, TypeScript, Node.js/NestJS, PostgreSQL, AWS).
• Proven ability to own system architecture and drive foundation-level decisions.
• Security-first mindset with knowledge of threat modeling and OWASP Top 10.

Responsibilities

• Own and evolve the architecture across data layer, API, frontend, and deployment infra.
• Build across the stack with production code in React, Node/NestJS, PostgreSQL on AWS.
• Design for multi-tenancy, including isolation, partitioning, and per-tenant config.
• Bake security into authentication, authorization, encryption, input validation, and API hardening.
• Profile, benchmark, and optimize performance across database, caching, and frontend.

Skills

React

TypeScript

Node.js/NestJS

PostgreSQL

AWS

Architecture ownership

Security mindset

Performance engineering

Ownership

AI-assisted development

Tools

Claude Code

Copilot

Job description

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning.

We’re looking for a Staff Software Engineer to help shape the architecture and technical direction of our core platform. The product is already in motion, and we need someone who can step in, assess what exists, strengthen the foundation, and drive it forward with the quality, security, and performance it demands.

We’re a small, fully remote engineering team (under 20) moving fast. You’ll play a central role in technical decision-making and work alongside experienced engineers to raise the bar across the system. Security and performance aren’t afterthoughts here; they’re core design constraints, and we need someone who treats them that way.

This is an early-stage company. That means you’ll wear many hats. Some weeks you’ll be deep in architecture decisions; other weeks you’ll be debugging a deployment pipeline, reviewing a junior engineer’s PR, or jumping into a customer escalation. If you need tightly defined boundaries, this isn’t the right fit. If you thrive when the scope is wide and the impact is direct, keep reading.

Reports to: Senior Engineering Manager

Location: Remote (India)

Responsibilities

• Own and evolve the architecture. Assess the current system, identify what needs to change, and drive the platform’s technical direction - data layer, API surface, frontend application, and deployment infrastructure.
• Build across the stack. Write production code daily in React, Node/NestJS, and PostgreSQL on AWS. You’re not directing from the sidelines; you’re in the codebase.
• Design for multi-tenancy at scale. Solve hard problems around tenant isolation, data partitioning, role-based access, and per-tenant configuration.
• Make security non-negotiable. Bake security into everything - authentication, authorization, data encryption, input validation, API hardening, and compliance readiness. Security isn’t a phase; it’s a design constraint.
• Obsess over performance. Profile, benchmark, and optimize across the stack - from database query plans and caching strategies to frontend rendering and bundle size. Build monitoring and alerting so you know when things degrade before users do.
• Build for scale. Architect with growth in mind - horizontal scaling, load management, connection pooling, async processing, and infrastructure that doesn’t buckle under increasing tenants and traffic.
• Set the engineering standard. Establish patterns, conventions, and quality bars that a growing team will build on top of. Write code that teaches.
• Mentor and uplevel. Help mid-level and senior engineers grow. Conduct design reviews, pair on hard problems, and raise the technical bar through collaboration, not gatekeeping.
• Champion modern tooling. Actively evaluate and adopt tools that make the team faster - including agentic coding tools like Claude Code. Experiment, form opinions based on evidence, and influence the team through merit, not mandates.
• Stay sharp. Keep a pulse on emerging trends in software engineering, AI-assisted development, infrastructure, and developer tooling. Bring what’s relevant back to the team.
• Wear whatever hat is needed. Jump into DevOps, debugging, customer support escalations, hiring interviews, or anything else the team needs. We value people who see a gap and fill it.

Requirements

• 8+ years of professional software engineering experience with a meaningful portion spent in full-stack roles building web applications at scale.
• Experience in high-ambiguity environments. You’ve operated in environments with high ambiguity, limited resources, and shifting priorities, and shipped anyway.
• Deep proficiency in modern web stacks. You have deep expertise in at least one modern web stack and are comfortable working across technologies like React, TypeScript, Node.js/NestJS, PostgreSQL, and AWS. You don’t just use these tools - you understand them.
• Proven ability to own system architecture. You’ve made foundational technical decisions, evolved existing systems, and lived with the consequences. You know what good (and bad) looks like because you’ve built it and fixed it.
• Security-first mindset. You understand OWASP Top 10, know how to prevent common vulnerabilities, and can design authentication and authorization systems that hold up under scrutiny. You think about threat modeling, not just happy paths.
• Performance engineering instincts. You can identify bottlenecks, design efficient data access patterns, and build systems that stay responsive under load. You know when to optimize and when it’s premature.
• Strong shipping discipline. You balance thoughtful design with pragmatic delivery. You know when to invest in abstraction and when to ship the simple thing.
• Enthusiasm for agentic coding and AI-assisted development. You’re already using tools like Claude Code, Copilot, or similar in your workflow and have informed opinions about where they accelerate and where they fall short.
• Bias for ownership and action. You default to action. When something is broken or unclear, you step in and fix it without being asked and take responsibility for the outcome.

Preferred Requirements

• Experience in healthcare, biotech, or life sciences - particularly with data platforms supporting clinical or research workflows.
• Experience with early-stage or growth-stage companies - building quality infrastructure under constraints, limited resources, shifting priorities, and fast release cycles.
• Experience designing developer-facing APIs or platform primitives consumed by other engineering teams.
• Background in event-driven architectures, CQRS, or domain-driven design.
• Familiarity with infrastructure-as-code (Terraform, CDK, or Pulumi) and CI/CD pipeline design.
• Experience with penetration testing, security audits, or SOC 2 / ISO 27001 compliance processes.
• Track record of evaluating and introducing new tools or frameworks to engineering teams based on measured outcomes.
• Contributions to open source or public technical writing that demonstrate how you think.