Staff Research Associate 1/2 - Neurological Surgery

UCSF Health, AG; Oakland (CA); Vor Ort; USD 65.000 - 90.000; Vollzeit

Zusammenfassung

UCSF Health, AG is seeking a Staff Research Associate to support the Neurosurgery Dept., the Helen Diller Comprehensive Cancer Center, and external collaborators. The role involves procuring brain tumor specimens, providing histology services, and maintaining a 46-year tissue repository.

You will perform tissue processing, data entry, and IHC with CLIA-compliant documentation. Responsibilities include operating core equipment, maintaining inventories, handling paraffin/frozen sections, DNA

Qualifikationen

• SRA I: BA/BS in Biology, Chemistry, Anatomy, or related science; or equivalent
• SRA II: BA/BS in Biology, Chemistry, Anatomy, or related science, plus 1 year of related work experience; or equivalent
• Experience with cell culture and basic laboratory techniques

Aufgaben

• Collect, process, and archive neurological tumor tissues and blood samples for Brain Tumor Center studies and clinical trials
• Data entry into Tissue Bank databases and sample tracking systems
• Operate and maintain core equipment (tissue processor, Ventana stainer, storage systems, microtome, cryostat)
• Process histology requests (paraffin or frozen sections)
• DNA isolation from tissue or blood samples
• Retrieve and verify consents; archive sample retrieval for histology or clinical requests
• Maintain human/animal cell cultures for distribution
• Perform immunohistochemical staining for core projects and investigators
• Maintain antibody inventory and update protocols; organize control slides
• Document CLIA-compliant clinical IHC work and instrument logs
• Quantify MIB-1 labeling index to assess tumor proliferation

Kenntnisse

Data management

Excel & Word

Cell culture basics

Laboratory techniques

Data entry

Multitasking

Ausbildung

BA/BS in Biology, Chemistry, Anatomy, or related science

One year of related work experience

Tools

Ventana Immunostainer

Automatic tissue processor

Microtome

Cryostat

Liquid nitrogen storage

Tissue Bank databases

Jobbeschreibung

Description & RequirementsJob Description

JOB SUMMARY

The Staff Research Associate (SRA) position will perform duties that are crucial to providing services to the UCSF Neurosurgery Dept., the Helen Diller Comprehensive Cancer Center and outside institutions. This employee will help procure brain tumor specimens from surgeries, provide histology services for both research and clinical purposes. The SRA will play an integral part in maintaining and building upon our 46-year-old repository.

Perform tissue collection, processing and other specialized histological and immunohistochemical tasks within a revenue-generating core facility in support of the UCSF Brain Tumor Center. Specifically, these tasks include:

• Collecting, processing and archiving neurological tumor tissues and blood samples for use by Brain Tumor Center investigators and for NeuroOncology clinical trials. These surgeries may occasionally run longer than scheduled and will require staying past 5pm.
• Data entry of patient and biospecimen information into Tissue Bank databases and sample tracking system.
• Operating and maintaining core equipment: automatic tissue processor, Ventana automated immunostainers, liquid nitrogen storage systems, microtome and cryostat.
• Processing histology requests that entails the generation of paraffin or frozen sections.
• DNA isolation from various sources of tissue or blood.
• Retrieve and verify consents.
• Archive sample retrieval (both frozen and paraffin) for histology or clinical requests
• Maintaining human and animal cell cultures to ensure adequate inventory in the Tissue Bank for distribution.
• Performing immunohistochemical staining for major Core projects as well as other individual investigators.
• Maintaining antibody inventory, tracking and updating protocol changes, organizing control slides in order to assure results and best utilize resources.
• Performing and documenting clinical IHC work: test slides, controls, instrument logs and pathologist review sheets as required by CLIA standards.
• Quantifying MIB-1 labeling index to predict tumor cell proliferation and invasiveness.

QualificationsRequired Qualifications:

• SRA I: BA/BS in Biology, Chemistry, Anatomy, or related science; or an equivalent combination of education and experience
• SRA II: BA/BS in Biology, Chemistry, Anatomy, or related science, including one year of related work experience; or an equivalent combination of education and experience
• Knowledge and experience of cell culture and basic laboratory techniques
• Experience managing large amounts of data for special projects
• Mathematical proficiency for preparing antibody dilutions
• Experience with basic lab procedures and instrumentation set-up
• Experience with basic sterile techniques for tissue culture cell line maintenance
• Demonstrated ability to follow instructions and multi-task to meet project deadlines; possess strong attention to details to ensure high quality data
• Proven proficiency with Microsoft Office Excel and Word

Preferred Qualifications:

• Competency with MS Access
• Experience operating with the Ventana Automated Immunostainer
• Experience working with human biospecimens
• Experience working in a CLIA laboratory and understanding the importance of maintaining patient confidentiality
• Experience with tissue collection, preparation and other related logistics for clinical trials