Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)

Natera; San Carlos (CA); Presencial; USD 170.000 - 212.000; Jornada completa

Descripción de la vacante

Natera is seeking a Staff Machine Learning and Bioinformatics Scientist to design models for Multi-Cancer Early Detection. You will work with large-scale genomic data, collaborating with biologists and clinicians to translate findings into clinically validated tools.

Responsibilities include developing novel ML/statistical methods, building interpretable models, prototyping at scale, and mentoring junior scientists to sustain scientific excellence.

Formación

• PhD required in a quantitative field with 6–12 years post-PhD experience.
• Hands-on experience with statistical and ML methods on complex biological data.
• Strong leadership and ability to guide research from prototype to validation.

Responsabilidades

• Lead development of novel statistical and ML methods for cancer signal detection on multi-modal genomic data.
• Build interpretable, well-calibrated models with uncertainty estimation and reproducibility.
• Prototype, test and productionize ML models using scalable infrastructure.
• Own technical deliverables and shape the research roadmap.
• Collaborate with molecular biologists and clinical scientists on experiments and validation.
• Share code and design improvements across projects.
• Translate results into clear stories for technical and non-technical audiences.
• Mentor junior scientists and foster collaboration and scientific excellence.

Conocimientos

Machine Learning

Bioinformatics

Deep Learning

Python

Statistical Methods

Genomics

Multi-modal Data

Educación

PhD in Computer Science / Mathematics / Bioinformatics

Herramientas

Python

Descripción del empleo

Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Staff Machine Learning and Bioinformatics Scientist to help design the models at the heart of that effort. You’ll work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. Your research will advance the state-of-the-art and you will drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients.

PRIMARY RESPONSIBILITIES:

• Lead the development of novel statistical and machine learning methods for cancer signal detection on multi-modal genomic data


• Build interpretable, well-calibrated models, setting the standard for uncertainty estimation and reproducibility across the group


• Prototype, test and productionize ML models using scalable infrastructure


• Own key technical deliverables within larger projects and help shape the team’s research roadmap


• Collaborate closely with molecular biologists and clinical experts on design and analysis of experiments and validation studies


• Keep raising the bar through code and design reviews across projects


• Translate complex results into clear stories for technical and non-technical audiences


• Mentor junior scientists and champion a culture of curiosity, collaboration, and scientific excellence

QUALIFICATIONS:

• PhD in Computer Science, Mathematics, Bioinformatics, or a related quantitative field with 6-12 years of experience post-PhD


• Hands‑on experience developing novel statistical / ML analysis methods applied to complex biological data


• Proven track record of innovation and technical leadership in complex method development projects


• Expertise in deep learning and multimodal foundation models


• Proficient in Python and its scientific computing ecosystem


• Scientific rigor throughout the R&D process, with eagerness to teach and learn new computational methods and biology


• Excellent communication skills and a collaborative approach across teams

Preferred Experience:

• Familiarity with DNA methylation and other epigenomic data


• Experience with cell‑free DNA and liquid biopsy samples


• Background in cancer genomics and diagnostics


• Hands‑on work with multimodal foundation models applied to biological data

Compensation & Total Rewards

This range reflects a good‑faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This positionis also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

Annual performance incentive bonus

Long‑term equity awards

401(k) with company match

Generous paid time off and company holidays

Additional wellness and work‑life benefits

Compensation Range

$169,800 - $212,300 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell‑free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world‑class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits — Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

If you are based in California, we encourage you to read this important information for California residents.

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Natera’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

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