Staff Accountant - San Francisco, CA

Osanni Bio; San Francisco (CA); On-site; USD 90,000 - 105,000; Full time

Job summary

Osanni Bio, a development-stage therapeutics company based in San Francisco, seeks a Staff Accountant to manage day-to-day accounts payable and PO operations within its hub-and-spoke finance model. The role collaborates with Clinical Operations, R&D, and CMC to ensure accurate payments and contract alignment.

The ideal candidate is detail-oriented, organized, and comfortable building scalable processes in a fast-paced biotech setting.

Qualifications

• Bachelor's degree in Accounting/Finance required.
• CPA or progress toward CPA a plus.
• 2–4 years of accounting experience with AP/PO ownership.
• Experience with hub-and-spoke finance or procurement models is a plus.

Responsibilities

• Own the full-cycle accounts payable process: invoice intake, coding, three-way matching, approvals, and vendor payments.
• Administer the purchase order process within the hub-and-spoke model, coordinating with department spokes.
• Coordinate with Clinical Operations, R&D, and CMC to align contracts with POs and invoices.
• Maintain the vendor master file, onboarding vendors, collecting W-9s and banking details, and prevent duplicate payments.
• Support month-end close with bank and balance sheet reconciliations, researching variances.
• Manage 1099 reporting and support sales and use tax compliance.

Skills

Attention to detail

Strong communication

Team collaboration

Problem solving

Adaptability

Education

Bachelor's degree in Accounting/Finance

CPA or progress toward CPA

Tools

QuickBooks

NetSuite

Sage Intacct

Bill.com

Ramp

Job description

Osanni Bio is a development-stage therapeutics platform, headquartered in San Francisco, California. We are creative and agile innovators, relentlessly curious about finding new ways to target the biology behind diseases with the greatest unmet need and determined to do something about it.

At the center of Osanni is its innovation engine, which is optimized for discovering new scientific insights, designing novel drug concepts, and efficiently advancing programs to a meaningful proof-of-concept. Once a program is sufficiently de-risked, it graduates into its ecosystem of affiliate companies, which are equipped with the dedicated focus, specialized talent and support necessary to scale. Osanni's architecture marries the scientific depth and operational power of a centralized platform with the speed, agility and accountability of independent companies. The result: an opportunity to create and deliver more transformative medicines.

We hold patients and the physicians who care for them as our North Star. It guides our purpose, sharpens our decision-making, and defines our impact. Osanni is currently advancing programs in ophthalmology, cardiology and beyond. We are building a highly skilled team, passionate about having an impact on human health. Be part of creating an organization where people enjoy their work and their colleagues, are valued for their individuality, and can't imagine working anywhere else.

Our Values:

Osanni is guided by three core values: Integrity + Impact, because we give a hoot; Agility + Accountability, so we swoop and soar; and Collaboration + Connection, to be one Osanni Flock. Together, they shape how our team shows up for patients, for each other, and for the mission.

*This position is based out of our SF/Bay area headquarters and is on-site 3 days per week

About the Role:

The Staff Accountant is responsible for Osanni's day-to-day accounts payable and purchase order operations and plays a key role in an accurate, timely month-end close. Operating as part of the central finance hub within Osanni's hub-and-spoke model, this role partners with department spokes across Clinical Operations, R&D, and CMC. As Osanni advances its programs and grows its ecosystem of affiliate companies, this role helps build the scalable processes and controls that support the business.

The ideal candidate is detail-oriented, organized, and service-minded, bringing strong operational discipline and sound judgment to every transaction. They are comfortable being hands-on, enjoy improving processes, and adapt well to shifting priorities in a fast-paced biotech environment. They hold themselves to a high standard of accuracy and accountability, reflecting Osanni's Agility + Accountability value, and build trusted relationships across teams in the spirit of the Osanni Flock.

What You Will Do:

• Own the full-cycle accounts payable process, including invoice intake, coding, three-way matching, approval routing, and timely vendor payments.
• Administer the purchase order process within Osanni's hub-and-spoke finance model, serving as the central hub that partners with department spokes on PO creation, approvals, change orders, and closeout.
• Partner with Clinical Operations, R&D, and CMC teams to align vendor contracts with POs, and invoices.
• Maintain the vendor master file, including onboarding new vendors, collecting W-9s and banking details, and enforcing controls that prevent duplicate or fraudulent payments.
• Assist with month end close performing bank reconciliations and balance sheet reconciliations researching and resolving variances.
• Manage annual 1099 reporting and support sales and use tax compliance and other regulatory filings.
• Support quarterly reviews and the annual audit by preparing schedules, pulling supporting documentation, and responding to auditor requests.
• Identify and implement improvements to AP and PO workflows, controls, and systems (e.g., ERP and AP automation tools) as Osanni scales.
• Manage multiple priorities in a fast-paced, evolving environment, ensuring deliverables are completed accurately and on time, while performing other related duties as required.

What You Bring:

• Bachelor's degree in Accounting, Finance, or a related field preferred; CPA or progress toward CPA a plus.
• 2 to 4 years of accounting experience, with hands-on ownership of accounts payable and purchase order processes.
• Experience working within a hub-and-spoke finance or procurement model, coordinating with decentralized department stakeholders on POs, approvals, and spend a plus.
• Understanding of accruals, and month-end close procedures, including journal entries and account reconciliations, preferred.
• Proficiency with ERP and accounting systems (e.g., Quickbooks, NetSuite, Sage Intacct) and AP or spend management tools (e.g., Bill.com, Ramp); strong Excel skills.
• Experience in biotech, pharma, or life sciences, preferred.
• Exceptional attention to detail and organization, with the ability to manage high transaction volumes accurately and meet deadlines.
• Use of AI and automation tools in accounting workflows desirable, with curiosity about applying AI responsibly to improve efficiency;
• Strong communication and interpersonal skills, discretion with confidential information, and a collaborative, service-oriented approach to working across teams.

The expected base pay range for this position is $90,000 - $105,000 plus bonus and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training.

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to be a part of building the future of transformative medicines, then we are excited to hear from you!