Sr. Scientist, Biologics Engineering

Biogen, Inc.; Cambridge (MA); On-site; USD 124,000 - 166,000; Full time

Benefits offered by this job

Medical/Dental/Vision Insurance

Wellness programs

Paid vacation

Holidays & time off

401(k) matching

Employee stock purchase

Job summary

Biogen is seeking a Sr. Scientist in Cambridge to design, engineer, and express recombinant proteins and antibodies, including bispecifics and fusion proteins.

You will lead hands-on cell culture work and balance efforts with external CRO protein production oversight. You will develop stable CHO cell lines, support purification and characterization, and contribute to project strategy while presenting findings to cross‑functional teams.

Qualifications

• Ph.D. in Biochemistry or related field with 2+ years industry experience, or a Master’s degree with 6+ years relevant industry experience.
• Strong expertise in molecular biology and protein engineering with demonstrated antibody design experience including bispecifics and fusion proteins.
• Hands‑on mammalian cell culture, transfection, and expression workflows for recombinant antibody production.
• Competence in purification and in‑vitro characterization techniques (e.g., SEC, Octet).
• Experience characterizing antibody binding, specificity, and cell‑surface target engagement using flow cytometry (FACS).
• Track record managing CRO relationships and external protein production.
• Strong organizational skills and attention to detail.
• Excellent communication and data presentation skills.

Responsibilities

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions using transient and stable expression platforms.
• Develop stable CHO cell lines for antibody expression as well as mammalian cell lines and reporters to support antibody discovery, screening, and lead optimization.
• Support protein purification and characterization activities, including assessment of antibody binding and cell‑surface target engagement using flow cytometry.
• Manage all aspects of protein production activities at CRO.
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings.
• Document experimental work clearly and completely in electronic lab notebooks and technical reports

Job description

About This Role The BioDesign group at Biogen is seeking an experienced and highly motivated scientist to contribute to the discovery and development of innovative biologic therapeutics. The Sr. Scientist will contribute to multiple research programs through the design, engineering, and expression of recombinant proteins, including antibodies and other biologic modalities. Leveraging expertise in molecular biology, protein engineering, and mammalian cell engineering, this individual will balance hands‑on laboratory research with oversight of external protein production efforts at CROs while collaborating across multidisciplinary project teams to advance the therapeutic pipeline.

What You’ll Do

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions using transient and stable expression platforms.
• Develop stable CHO cell lines for antibody expression as well as mammalian cell lines and reporters to support antibody discovery, screening, and lead optimization.
• Support protein purification and characterization activities, including assessment of antibody binding and cell‑surface target engagement using flow cytometry.
• Manage all aspects of protein production activities at CRO.
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings.
• Document experimental work clearly and completely in electronic lab notebooks and technical reports

Who You Are

You are an independent and innovative scientist with strong expertise in molecular biology, antibody engineering, and mammalian cell culture. You enjoy working in a collaborative, team‑oriented environment and are motivated by solving complex scientific challenges. You have a track record of scientific achievement, strong communication skills, and the ability to balance multiple priorities while contributing to shared team goals.

Required Skills

• Ph.D. in biochemistry or a related field with 2+ years experience industry experience, or a Master’s degree with 6+ years relevant industry experience.
• Strong expertise in molecular biology and protein engineering, with demonstrated experience designing antibodies and novel antibody‑based formats, including biospecifics and fusion proteins.
• Hands‑on experience developing and executing mammalian cell culture, transfection, and expression workflows for recombinant antibody production.
• Competence in protein purification and in‑vitro analytical characterization techniques (e.g., SEC, Octet,).
• Experience characterizing antibody binding, specificity, and cell‑surface target engagement using flow cytometry (FACS)-based assays.
• Track record of managing CRO relationships and external protein production.
• Strong organizational skills and attention to detail.
• Excellent communication and data presentation skills.

Preferred Skills

• Direct experience with antibody‑oligonucleotide conjugates and other complex modalities.
• Expertise in advanced cell engineering technologies including lentiviral transduction and gene editing technologies.
• Familiarity with mass spectrometry‑based characterization of antibody therapeutics and engineered biologics.

Job Level: Management

Additional Information

The base compensation range for this role is: $124,000.00-$166,000.00 Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short term and long‑term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well‑being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short‑and Long‑Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end‑of‑year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid‑sized biotechnology company, we provide the stability and resources of a well‑established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life‑changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives. At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law.

Biogen is an E-Verify Employer in the United States.