Sr. Scientist, Biologics Engineering

Biogen; Cambridge (MA); On-site; USD 124,000 - 166,000; Full time

Benefits offered by this job

Medical, Dental, Vision, & Life ins.

Tuition reimbursement

401(k) program with match

Paid vacation and holidays

Employee stock purchase plan

Job summary

Biogen is seeking an experienced Sr. Scientist in the BioDesign group to contribute to discovery and development of biologic therapeutics.

The role combines hands-on molecular biology, protein engineering, and mammalian cell engineering with oversight of CRO production efforts. You will design and express recombinant proteins and antibodies, build stable cell lines, and lead characterization and purification activities, while collaborating across multidisciplinary teams to advance therapeutic

Qualifications

• Ph.D. with 2+ years industry experience or M.S. with 6+ years industry experience.
• Strong expertise in molecular biology and protein engineering, including antibody design.
• Hands-on mammalian cell culture, transfection, and expression workflows.

Responsibilities

• Design, engineer, and express recombinant proteins and antibodies, including bispecifics and fusions.
• Develop stable CHO and mammalian cell lines for expression and screening.
• Support protein purification and characterization, incl. flow-based target engagement.
• Manage protein production activities at CROs and oversee external work.
• Present findings at team meetings and document work in ELNs.

Skills

Molecular biology

Protein engineering

Mammalian cell culture

Flow cytometry (FACS)

Project coordination

Data presentation

Documentation

Education

Ph.D. in biochemistry or related field

M.S. with 6+ years industry experience

Tools

SEC

Octet

FACS instrumentation

Job description

About This Role

The BioDesign group at Biogen is seeking an experienced and highly motivated scientist to contribute to the discovery and development of innovative biologic therapeutics. The Sr. Scientist will contribute to multiple research programs through the design, engineering, and expression of recombinant proteins, including antibodies and other biologic modalities. Leveraging expertise in molecular biology, protein engineering, and mammalian cell engineering, this individual will balance hands-on laboratory research with oversight of external protein production efforts at CROs while collaborating across multidisciplinary project teams to advance the therapeutic pipeline

What You’ll Do

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions using transient and stable expression platforms.
• Develop stable CHO cell lines for antibody expression as well as mammalian cell lines and reporters to support antibody discovery, screening, and lead optimization.
• Support protein purification and characterization activities, including assessment of antibody binding and cell-surface target engagement using flow cytometry.
• Manage all aspects of protein production activities at CRO.
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings.
• Document experimental work clearly and completely in electronic lab notebooks and technical reports.

Who You Are

You are an independent and innovative scientist with strong expertise in molecular biology, antibody engineering, and mammalian cell culture. You enjoy working in a collaborative, team-oriented environment and are motivated by solving complex scientific challenges. You have a track record of scientific achievement, strong communication skills, and the ability to balance multiple priorities while contributing to shared team goals.

Required Skills

• Ph.D. in biochemistry or a related field with 2+ years experience industry experience, or a Master's degree with 6+ years relevant industry experience.
• Strong expertise in molecular biology and protein engineering, with demonstrated experience designing antibodies and novel antibody-based formats, including biospecifics and fusion proteins.
• Hands-on experience developing and executing mammalian cell culture, transfection, and expression workflows for recombinant antibody production.
• Competence in protein purification and in vitro analytical characterization techniques (e.g., SEC, Octet).
• Experience characterizing antibody binding, specificity, and cell-surface target engagement using flow cytometry (FACS)-based assays.
• Track record of managing CRO relationships and external protein production.
• Strong organizational skills and attention to detail.
• Excellent communication and data presentation skills.

Preferred Skills

• Direct experience with antibody-oligonucleotide conjugates and other complex modalities.
• Expertise in advanced cell engineering technologies including lentiviral transduction and gene editing technologies.
• Familiarity with mass spectrometry-based characterization of antibody therapeutics and engineered biologics.

Job Level: Management

Additional Information

The base compensation range for this role is: $124,000.00-$166,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being ; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning,