Sr. Scientist / Associate Director Immunology and Inflammation

Monte Rosa Therapeutics; Boston (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Monte Rosa Therapeutics is seeking a Discovery Immunologist to join our Boston team. This role emphasizes strategic scientific contributions and hands-on work towards developing first-in-class medicines targeting immunology-related diseases. The ideal candidate will possess significant experience in drug discovery, leadership, and a passion for innovation in science.

Qualifications

• 5+ years hands-on experience in drug discovery research in an industrial setting.
• Strong understanding of autoimmune and inflammatory diseases.
• Experience managing and mentoring direct reports.

Responsibilities

• Review potential targets for therapeutic potential in non-oncology diseases.
• Devise and implement biology strategy to drive target progression.
• Develop assays to determine downstream effects of target degradation.

Skills

Immunology

Drug Discovery

Cell Biology

Flow Cytometry

Assay Development

Protein Degradation

Project Management

Communication

Education

PhD or Postdoc equivalent in Immunology

Tools

Western Blotting

ELISA

qRT-PCR

CRISPr/shRNA

Job description

Overview

Monte Rosa Therapeutics is looking for an energetic and self-motivated Discovery Immunologist who will join our Boston based, Immunology & inflammation discovery biology team . Will be responsible for leveraging our novel platform to develop first-in-class medicines and new chemical modalities This role includes both strategic scientific thinking & hands on bench-work. The candidate will make critical contributions to target identification & validation, progression & translational application of molecular glue degraders for immunology-related targets. The ideal candidate brings expertise in immunology, development of assays to test immune cell functions, translational application and a background in industrial small molecule drug discovery.

Responsibilities

• Review potential targets identified by our platform for therapeutic potential in non-oncology -related diseases with emphasis on autoinflammatory/immunology diseases
• Devise & implement biology strategy to drive target progression towards strategic milestones (biology program leadership)
• Develop relevant assays to determine downstream effects of target degradation (e.g. signaling, viability, cytokine secretion, function) & link phenotypes with disease biology
• Interpret, present and report research findings at internal meetings and external scientific conferences in relevant context
• Work collaboratively in a cross-functional team (e.g. chemistry, proteomics, data science, discovery sciences, animal care facility)

Qualifications

• PhD or Postdoc equivalent in Immunology with 5+ years hands-on experience in drug discovery research in an industrial setting
• Project lead experience and/or driving preclinical immunology-related targets towards milestones
• Strong understanding of key drivers of autoimmune and inflammatory diseases & passion for science and innovation
• Proficient in immune cell isolation and multi-parameter flow cytometry
• Extensive technical expertise in primary immune cell functional assay development
• Experience with a variety of molecular & cell biology methods and assays such as western blotting, JESS/WES, ELISA, qRT-PCR, CRISPr/shRNA, cytokine secretion, transcriptomics
• Ability to implement and/or oversee in vivo and ex vivo murine studies
• Experience with external CROs to support project progression and meet deadlines
• Demonstrated ability to work in a dynamic, action-oriented, cross-functional team environment
• Experience managing and mentoring direct reports
• Excellent communication skills and ability to articulate scientific results and implications in a concise and context-dependent manner
• Excellent organizational & time management skills with flexibility to accommodate rapidly changing priorities and deadlines
• Protein degradation experience is a plus