Research Associate/Senior Research Associate –Discovery Biology

Monte Rosa Therapeutics Inc.; Boston (MA); On-site; USD 70,000 - 100,000; Full time

Job summary

Monte Rosa Therapeutics is looking for a Research Associate/Senior Research Associate - Biology to support early target validation in immunology and inflammation. You will engage in hands-on laboratory work, conducting in vitro experiments and collaborating with teams to advance molecular glue degraders into clinical applications.

Qualifications

• 1-3 years of relevant hands-on experience in an industrial research setting.
• Proficiency in techniques outlined for assay development and execution.
• Familiarity with ex vivo assays or whole blood assays is preferred.

Responsibilities

• Assist in planning and implementing experimental protocols for Molecule Glue Degraders.
• Develop and optimize in vitro functional assays using primary immune cells.
• Maintain accurate laboratory records and collaborate with cross-functional teams.

Skills

Primary cell isolation and culture techniques

Documentation and record-keeping skills

Education

Bachelor’s or Master’s degree in Immunology, Molecular Biology, Cell Biology

Tools

Flow cytometry

ELISA

MSD

Western blot

Job description

Overview

Monte Rosa Therapeutics is seeking a Research Associate/Senior Research Associate - Biology to support early target validation in immunology and inflammation, aiding in the advancement of our molecular glue degraders into clinic. The successful candidate will collaborate with team members to design and execute in vitro experiments focused on discovery andvalidation of discovery biologyprojects as well as determining the activity and mechanism of action of compoundsin later phase programs. This role requires hands-on laboratory work, conducting a variety of in vitro experiments.

Responsibilities

• Assist in the planning and implementation of diverse experimental protocols aimed at evaluating the efficacy and mechanism of action of Molecule Glue Degraders.
• Develop, optimize, and execute in vitro functional assays using primary immune cells to assess cellular responses, cytokine production, and other immunological parameters.
• Support downstream analytical techniques including flow cytometry, ELISA, MSD, and Western blotting to validate experimental outcomes.
• Perform routine and specialized cell culture procedures, including the maintenance and handling of primary immune cells and established cell lines, to support in vitro studies.
• Maintain accurate and detailed laboratory records of experimental design, protocols, raw data, and analyzed results in accordance with internal documentation standards.
• Work closely with cross-functional teams, including senior scientists and project managers, to ensure alignment of experimental strategies with project goals.

Qualifications

• Bachelor’s or Master’s degree in Immunology, Molecular Biology, Cell Biology, or a closely related scientific discipline.
• Minimum of 1-3 years of relevant hands-on experience in an industrial research setting.
• Proficiency in primary cell isolation and culture techniques.
• Familiarity with standard molecular and cell biology techniques, including flow cytometry, ELISA, MSD, and Western blot.
• Experience with ex vivo assays or whole blood assays preferred.
• Strong attention to detail, with excellent documentation and record-keeping skills.