Sr Scientist

BioSpace; Thousand Oaks (CA); On-site; USD 130,000 - 170,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental & vision insurance

Life and disability insurance

Flexible spending accounts

Annual bonus program

Stock-based incentives

Generous paid time off

Flexible work models

Job summary

Amgen seeks a Senior Scientist in Thousand Oaks to advance mass spectrometry-based proteomics and high-throughput workflows. You will deliver insights for target identification and drug discovery while improving screening platforms.

The role requires hands-on expertise with automated mass spec systems and collaboration across chemistry and biology teams to drive data-informed decisions and pipeline support.

Qualifications

• PhD/MD/PharmD in proteomics or related field required or equivalent.
• Experience with high-throughput proteomics and LC-MS/MS platforms.
• Strong collaboration and data-driven decision-making skills.

Responsibilities

• Design and optimize high-throughput mass spectrometry proteomics workflows.
• Execute automated sample prep and LC-MS/MS analyses across assays.
• Collaborate with chemistry and biology teams as SME on proteomics.
• Analyze data to reveal mechanism of action and target engagement.
• Present findings and maintain detailed, reproducible documentation.
• Maintain organized records of experiments and protocols.

Skills

Mass spectrometry

Proteomics workflows

High-throughput screening

LC-MS/MS

Data analysis

Cross-functional collaboration

Automation & miniaturization

Education

PhD/MD/PharmD in proteomics or related field

MS in related field +4 years experience

BSc +6 years related experience

Tools

Orbitrap Astral

Automated sample prep

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr Scientist

What You Will Do

Lets do this. Letschange the world.

We are seeking a motivated Senior Scientist in mass spectrometrybased proteomics to join our talentedand collaborativeteam in Thousand Oaks, CA. In this vital role, you will deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies.

You will contribute to bothpipeline advancement and screening platform innovationby developing and implementingcutting-edge, high-throughput proteomics approaches. This includes executing automated sample preparation and mass spectrometry analyses across a range of assays, as well as designing,optimizing, and continuouslyenhancing next-generation screening workflows and analytical platforms.

This role requires hands-on experienceoperatingand troubleshooting high-throughput mass spectrometry systems. Your work will play a key role in enabling innovative drug screening strategies, accelerating discovery efforts, and strengthening pipeline support.

• Design,develop, andoptimizehigh-throughputmass spectrometrybased proteomics workflows and screening platforms to accelerate drug discovery
• Execute automated sample preparation and LC-MS/MS analysis across abroadrange of high-throughput proteomicsassays
• Collaborate closely with chemistry, biology, and disease area teams as a technical and scientific subject matter expert, contributing to data-driven decision-making
• Perform data analysis and generate insights into mechanism of action, target engagement, and selectivity using proteomicsapproaches
• Present research findings at internal and external meetings and effectively communicate plans, results, and analyses to cross-functional teams
• Maintainaccurateand organized documentationof experiments, protocols, and analyses

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist weseekis a scientifically driven, collaborative, and innovative proteomics expert.

Basic Qualifications

• Doctorate degree (PhD, PharmD, or MD) with relevant experienceOR
• Masters degree and 4 years ofdirectly relatedexperienceOR
• Bachelors degree and 6 years ofdirectly relatedexperience

Preferred Qualifications

• Doctorate degree in proteomics,chemoproteomics, biochemistry, chemistry, ora relateddiscipline
• Strongtrack recordin developing mass spectrometrybased proteomics assays,operatingadvanced platforms (e.g., Orbitrap Astral), and analyzing proteomics data
• Experience with sample preparation miniaturization and automation platforms
• 3+ years of experience in the biotech or pharmaceutical industry
• Demonstrated innovation inassay,method, or platformdevelopment
• Strong quantitative and computationalexpertiseinhigh-dimensionalproteomicsdata analysis
• Ability to work effectively in a highly integrated, collaborative team environment, with excellent organizational, verbal, and written communication skills, and a proventrack recordof producing reliable and reproducible results.
• Knowledge of targeted protein degradation or E3 ligase biology is a plus

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.