Sr. Scientist

SEVENTH WAVE LABORATORIES LLC; Missouri; On-site; USD 110,000 - 160,000; Full time

Benefits offered by this job

Health and dental coverage

Disability insurance (short/long-term)

Paid time off

Paid parental leave

401K with company match

Job summary

Inotiv is seeking a Senior Scientist – Bioanalytical Method Development to lead LC-MS/MS and HRMS method development for large and small molecules. You will work within the DMPK team to feasibility assess new proposals and support method transfers.

You will mentor junior scientists, adhere to SOPs and regulatory guidelines, and coordinate multi-project workflows while communicating progress to stakeholders. Strong expertise in bioanalysis is required.

Qualifications

• PhD or MSc with significant industrial bioanalytical experience.
• Experience with LC-MS/MS and HRMS in bioanalysis of large and small molecules.
• Strong knowledge of SOPs, GMP/GLP concepts and regulatory expectations.

Responsibilities

• Develop highly sensitive LC-MS/MS and HRMS methods for large and small molecules in biological matrices.
• Lead method development projects and troubleshoot challenging assays.
• Coordinate method transfers and client-driven transfers across groups.
• Communicate project timelines, status and data to PIs and clients.
• Manage multiple projects and meet deadlines in a fast-paced environment.
• Mentor junior scientists and contribute to departmental growth.

Skills

Bioanalytical mass spectrometry

Method development

SOPs/GLP compliance

Data analysis

Education

PhD in Organic Chemistry / Biochemistry / Analytical Chemistry

MSc in relevant discipline

Tools

LC-MS/MS

HRMS

Job description

Senior Scientist – Bioanalytical Method Development LC-MS/MS

The Senior Method Development Scientist will perform method development utilizing contemporary mass spectrometry techniques (LC‑MS/MS & HRMS) for large and small molecules (proteins, antibodies, ADCs oligonucleotides, etc.). The senior method development scientist will be a member of the DMPK team and will serve as a subject matter expert for new proposals, evaluating feasibility of LC‑MS/MS method development, and troubleshooting challenging methods across a wide variety of species and matrices. Join us in embracing research and science to impact the health and well-being of people all over the world.

Essential Duties and Responsibilities

• Develop highly sensitive LC‑MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
• Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accepts leadership role in developing novel scientific approaches
• Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
• Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
• Ability to coordinate and execute on multiple projects simultaneously and responsive to unscheduled deadlines and client needs.
• Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58) as these relate to study‑specific services provided, this job description, and general facility operations.
• Training and mentoring junior scientists within and across departments
• Collaborate with leadership on long‑range planning and strategy for departmental growth
• Performs other duties as assigned.

Skills and Abilities

• Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC‑MS/MS, HRMS), instrument operation, maintenance, and data processing.
• Proven track record of method development for large and small molecules
• Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
• Working knowledge of laboratory software, system software, and Microsoft applications
• Independence in the laboratory and data work‑up phases of research.
• A working knowledge and awareness of general laboratory procedures.
• Good written and oral communication skills.
• Ability to adhere to all safety regulations and procedures.

Education and Experience

PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training

M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience

Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable

Physical Activity and Working Conditions

Work is normally performed in a typical interior office work or laboratory environment Work environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment The noise level is usually moderate This position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro‑mechanical hazards, flammable materials and bio‑hazards. Due to exposure to hazardous biological material (which may include HIV positive specimens), immunization to Hepatitis B and/or other diseases may be a requirement.

Salary will be commensurate with experience and responsibilities.

Benefits

• Benefits include health and dental coverage, short- and long‑term disability, paid time off, paid parental leave, 401K participation with company match, and more!

Inotiv is an Equal Opportunity Employer.

It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, gender, gender identity, sexual orientation, physical or mental disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training.

*This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person’s relevant experience and/or education level.

At Inotiv, our work helps advance the development of new medicines and therapies that can improve people's lives. As a leading global contract research organization (CRO), we partner with researchers to tackle complex scientific challenges, drive innovation, and help build a healthier, safer world. Bringing together scientists, researchers, technical experts, and business professionals, we provide the expertise and collaboration needed to move research forward. Our people make this work possible, and we value the knowledge, ideas, and contributions each person brings to the team. Whether you are starting your career or bringing years of experience, Inotiv offers opportunities to learn, grow, and play a meaningful role in advancing treatments for patients around the world.

Salary will be commensurate with experience and responsibilities.

Benefits

• Benefits include health and dental coverage, short- and long‑term disability, paid time off, paid parental leave, 401K, and more!

Inotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, sex, gender, gender identity, gender expression, sexual orientation, genetic information, disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training. At Inotiv, our people are our greatest asset. We are committed to equality, opportunity, and diversity, and treating our colleagues with the dignity and respect they deserve. We strive to ensure that our people achieve their full potential, and that they enjoy a rewarding career with us.

*This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person’s relevant experience and/or education level.

At Inotiv, our work helps advance the development of new medicines and therapies that can improve people's lives. As a leading global contract research organization (CRO), we partner with researchers to tackle complex scientific challenges, drive innovation, and help build a healthier, safer world. Bringing together scientists, researchers, technical experts, and business professionals, we provide the expertise and collaboration needed to move research forward. Our people make this work possible, and we value the knowledge, ideas, and contributions each person brings to the team. Whether you are starting your career or bringing years of experience, Inotiv offers opportunities to learn, grow, and play a meaningful role in advancing treatments for patients around the world.

We’re looking for people who will help us grow and support our shared purpose: to help our clients discover and develop life‑changing therapies for people around the world.

As a leading contract research organization (CRO), Inotiv supports discovery and nonclinical development through investigational new drug (IND) and beyond.

By leveraging our deep expertise and scientific capabilities, we help you increase efficiency, improve data, and reduce the cost of taking new drugs to market.

By providing critical research models and related services, we help researchers realize the full potential of their R&D projects, all while working together to build a healthier and safer world.