Sr. Research Associate

Revolution Medicines; Redwood City (CA); On-site; USD 70,000 - 110,000; Full time

Job summary

A leading company in precision oncology is seeking a scientist to develop advanced LC-MS/MS and HRMS methods for drug quantification in order to support critical ADME and pharmacokinetic studies. Candidates should possess a degree in pharmaceutical sciences with substantial experience in bioanalytical methods and instrumentation.

Qualifications

• 5+ years relevant industry experience or 3+ years postgraduate.
• Experience in operating LC-MS/MS and HRMS systems.
• Knowledge of biological sample preparation for analysis.

Responsibilities

• Develop LC-MS/MS and HRMS methods for quantification.
• Perform mechanistic in vitro ADME assays.
• Generate reports and archive data.

Skills

LC-MS/MS operation

Method development

Data analysis

Communication

Education

Bachelor/Master’s in Pharmaceutical Sciences

Tools

SCIEX QTRAP

Thermo Scientific Q Exactive

HPLC/UPLC

Job description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Develop LC-MS/MS-based methods for quantification of compounds in various matrices (buffer, blood, plasma, tissue homogenates, etc) to support in vitro ADME, pharmacokinetic, and toxicokinetic studies.
Develop high-resolution mass spectrometry (HRMS) methods for metabolite identification and profiling studies for preclinical and clinical samples.
Perform mechanistic in vitro ADME assays, such as metabolic stability studies in various biological matrices (including hepatocytes, microsomes, blood, plasma, etc.).
Perform data analysis, generate experimental reports, and present the data to teams; Archive raw data and finalized reports to electronic system and electronic notebook.
Assist in the operation, maintenance, and troubleshooting of LC-MS/MS instruments.
Ensure a safe and well-organized DMPK lab environment.

Required Skills, Experience, and Education:

• Bachelor/Master’s degree in Pharmaceutical Sciences or a related scientific discipline, with 5+ of relevant industry experience or 3+ years of postgraduate working experience.
• Hands-on experience in operating and maintaining an LC-MS/MS system and/or a High-Resolution MS system.
• Hands-on experience in LC-MS method development for bioanalytical analysis and/or metabolite identification studies.
• Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS and/or HRMS analysis.
• Ability to conduct multiple laboratory and project tasks efficiently.
• Ability to work in a team-oriented environment with flexibility.
• Highly organized, detail-oriented, excellent record-keeping skills, and being able to adapt to a dynamic and fast-paced environment.
• Strong written and verbal communication skills, with a demonstrated ability to collaborate effectively in a team environment.

Preferred Skills:

• Hands-on experience in SCIEX QTRAP and/or Thermo Scientific Q Exactive mass spectrometers.
• Hands-on experience in HPLC/UPLC method development and/or bioanalytical method development in compliance with regulatory requirements.
• Working experience in DMPK lab.