Sr. Manager, Bioinformatics

Illumina; United States; Remote; USD 171,000 - 256,000; Full time

Benefits offered by this job

Bonus program eligibility

Equity compensation

Comprehensive benefits

Job summary

Illumina is seeking a Sr. Manager, Bioinformatics to lead a team supporting Clinical Genomics products including oncology and regulated sequencing solutions.

You will oversee analytics development, validation, and deployment of bioinformatics workflows, collaborating across R&D, software, regulatory, and commercial teams. The role requires strong leadership, experience with regulated devices, and expertise in NGS data analysis using Python, R, and Linux.

Qualifications

• Bachelor’s degree required with 12+ years of related experience; 3–6 years of management experience.
• PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, Genomics, or related field with 8+ years preferred.
• Demonstrated leadership in managing bioinformatics teams and complex programs.
• Experience with regulated products (IVD, CDx, FDA, IVDR) or similar.
• Strong NGS/genomics data analysis and bioinformatics pipeline development.
• Experience deploying genomics products with customers/commercial teams.
• Proficiency with Python, R, and Linux-based environments.
• Excellent communication and stakeholder management skills.

Responsibilities

• Lead, mentor, and develop a team of bioinformatics scientists.
• Manage bioinformatics activities across Clinical Genomics product development and lifecycle.
• Oversee development, validation, and deployment of analytical methods and workflows.
• Collaborate with R&D, Software, Biostatistics, Regulatory, Quality, PM, and Commercial teams.
• Partner with customers and collaborators to support product adoption and troubleshoot challenges.
• Drive evaluation and adoption of new analytical approaches and scalable solutions.

Skills

Leadership

Communication

Stakeholder management

Team collaboration

Education

Bachelor’s degree

PhD in Bioinformatics/Computational Biology/CS/Statistics/Genomics

Tools

Python

R

Linux

Job description

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

The Sr. Manager, Bioinformatics will lead a team of bioinformatics scientists supporting Illumina’s Clinical Genomics portfolio, including oncology, reproductive health, and regulated clinical sequencing products. This leader will oversee bioinformatics activities supporting assay development, software releases, regulatory submissions, and product commercialization. The role will partner closely with cross-functional teams to deliver high-quality bioinformatics solutions that support product development and customer success.

Responsibilities

• Lead, mentor, and develop a team of bioinformatics scientists while fostering a culture of collaboration, innovation, and technical excellence.
• Manage bioinformatics activities supporting Clinical Genomics product development, commercialization, and lifecycle management, including portfolio prioritization, resource allocation, and risk management across multiple programs.
• Oversee development, validation, and deployment of analytical methods and bioinformatics workflows that support customer-facing software, assays, and regulated products.
• Collaborate across R&D, Software Engineering, Biostatistics, Regulatory, Quality, Product Management, and Commercial teams to achieve program objectives and business goals.
• Partner with customers, commercial teams, and external collaborators to support product adoption, provide bioinformatics expertise, troubleshoot complex technical challenges, and gather feedback to improve products and workflows.
• Drive evaluation and adoption of new analytical approaches, technologies, and scalable bioinformatics solutions that advance product capabilities, operational efficiency, and customer value.
• Listed responsibilities are an essential, but not exhaustive, list of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.

Requirements

• Typically requires a Bachelor’s degree and a minimum of 12 years of related experience, with 3-6 years of Management experience.
• PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, Genomics, or related scientific discipline, with 8+ years of relevant experience preferred
• Demonstrated leadership experience managing bioinformatics teams and complex cross-functional programs.
• Experience supporting regulated products, including IVD, CDx, FDA, IVDR, or similar regulatory frameworks.
• Strong understanding of next‑generation sequencing, genomics data analysis, and bioinformatics pipeline development.
• Experience supporting customers, commercial teams, or external collaborators in the deployment and adoption of genomics products and bioinformatics solutions.
• Proficiency with bioinformatics software development and analysis tools, including Python, R, and Linux-based environments.
• Excellent communication, stakeholder management, and organizational leadership skills.

All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

#LI-REMOTE

The estimated base salary range for the Sr. Manager, Bioinformatics role based in the United States of America is: $170,600 - $255,800. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long‑term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [e-mail]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.