Sr. Manager/Associate Director Chemistry

Corvus Pharmaceuticals; South San Francisco (CA); On-site; USD 160,000 - 195,000; Full time

Job summary

Corvus Pharmaceuticals, Inc. in South San Francisco is seeking a senior chemist to independently design synthetic strategies and create precursor compounds, intermediates, and new chemical entities.

You will design small-molecule drug candidates using biological activity, ADME/PK, and IP-relevant data. The role requires a PhD in Chemistry with 5+ years in pharma/biotech, and expertise in synthetic organic chemistry with strong analytical skills (NMR, HPLC, MS).

Qualifications

• PhD in Chemistry with 5+ years of pharma/biotech experience.
• Demonstrated expertise in synthetic organic chemistry.
• Expert knowledge of scientific principles and concepts.
• Solid understanding of modern analytical techniques (NMR, HPLC, MS).
• Excellent verbal and written communication; ability to collaborate in a multidisciplinary team.

Responsibilities

• Independently design synthetic strategies and prepare precursors, starting materials, intermediates, reference compounds, and new chemical entities.
• Design small-molecule drug candidates based on in vitro/in vivo data, ADME/PK, and IP-relevant data.
• Purify and characterize molecules with analytical techniques (e.g. NMR, HPLC, MS).
• Use computation and structural data to aid design of molecules.
• Collaborate with chemistry and biology teams to perform R&D, observe and analyze data.

Skills

Synthetic organic chemistry

Education

PhD in Chemistry

Tools

NMR

HPLC

MS

Job description

Base pay range

$160,000.00/yr - $195,000.00/yr

Role and Responsibilities

• Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
• Design small-molecule drug candidates based on in vitro and in vivo biological activity, ADME/PK, physicochemical and IP-relevant data.
• Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
• Use computation and structural data and information to design molecules
• Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyzes data.
• Prepare batch records, technical reports, summaries, protocols and quantitative analyses
• Write and review manuscripts for publication
• Provide support in corporate research and development of patent applications
• Develop strategies to ensure effective achievement of scientific objectives
• Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
• Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results

Qualifications and Education Requirements

• PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.
• Demonstrated expertise in synthetic organic chemistry
• Must possess expert knowledge of scientific principles and concepts.
• A solid understanding of modern analytical techniques (NMR, HPLC, MS)
• Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team

Preferred Skills

• Experience in designing and synthesizing PROTACs or molecular glues is strongly preferred
• Molecular modeling and computational methods
• Able to manage outside vendor collaborations
• Flexibility and willingness to solve problems that fall outside of immediate area of expertise
• Work independently in an interdisciplinary, fast-paced, often changing environment.
• Committed to the values of integrity, accountability, transparency, and drive.

Local candidates only.

Salary Range: $160,000 to $195,000

Employment type

• Full-time

Job function

• Science

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