Scientist, Chemistry

Treeline; Watertown (MA); On-site; USD 110,508 - 141,560; Full time

Job summary

A biotech company in Watertown, MA seeks a Scientist for Chemistry to propose and characterize molecules as potential therapeutics for oncology. The role includes designing synthetic routes, solving purification challenges, and conducting data-driven decisions in drug discovery. Candidates should possess a PhD in organic chemistry and expertise in synthetic techniques. A competitive salary between $110,508 and $141,560 is offered, depending on experience and qualifications.

Qualifications

• 0–5 years industry experience and/or postdoctoral training in medicinal chemistry.
• Compelling medicinal chemistry experience in synthesis, purification, and characterization.
• Ability to maintain excellent documentation of work.

Responsibilities

• Design and improve synthetic routes to support SAR studies.
• Resolve synthetic, characterization and purification challenges.
• Drive data‑driven Go/No‑go decisions for oncology drug discovery.

Skills

Synthetic organic chemistry

Excellent collaboration skills

Strong analytical and organizational skills

Excellent communication skills

Proficiency in SciFinder

Proficiency in ChemDraw

Education

PhD in organic chemistry or related field

Tools

SciFinder

Chemdraw

Job description

Scientist, Chemistry at Treeline Biosciences

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About Treeline Biosciences

Treeline Biosciences is a new biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult‑to‑drug targets in cancer and other life‑threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, structural biology, medicinal chemistry, and computation to reduce the time and risks of drug discovery.

About The Role

A Scientist of Chemistry is primarily responsible for proposing, synthesizing, and characterizing molecules as potential oncology therapeutics. The scientist will be responsible for driving the advancement of oncology programs and platforms by optimizing the potency, pharmacokinetics, safety and in vivo efficacy of potential oncology drugs.

Responsibilities

• Design and improve synthetic routes to support SAR studies in a timely manner.
• Solve synthetic, characterization and purification challenges of complex molecules.
• Generate hypotheses, independently execute experiments, and use results to assist in the design of the next experiment.
• Recognize problems and provide input on solutions, suggest new approaches to established procedures to progress key drug discovery.
• Critically evaluate project data while rigorously driving data‑driven Go/No‑go decisions, including the identification of resource constraints and bottlenecks.
• Promote an overall group culture of agility, pro‑action, collaboration, and innovation.
• Mentor and develop internal talent.

Qualifications

• PhD in organic chemistry or related field (0–5 years industry experience and/or postdoctoral training) with compelling medicinal chemistry experience.
• Demonstrated expertise in synthetic organic chemistry with a record of productivity in the design, synthesis, purification, and characterization of challenging organic molecules using state‑of‑the‑art techniques.
• Excellent literature search skills, the ability to design and improve synthetic routes to support SAR studies and deliver compounds on suitable scale required to support research programs.
• Highly motivated, creative, and able to maintain excellent documentation of work with knowledge of cutting‑edge medicinal chemistry and synthetic chemistry techniques.
• Candidates must possess excellent collaboration skills, demonstrate strong analytical and organizational skills, and work effectively under aggressive timelines.
• Strong computer skills, including SciFinder, Chemdraw, and related software.
• Excellent communication skills and the ability to report and present data to colleagues and senior management is required.

Salary: $110,508 to $141,560 annually (Watertown, MA). The final base salary will depend on experience, education, and other factors. Treeline is a multi‑state employer; this range may vary for positions in other cities or states.