Sr. Engineer – DSP Location – Boulder, CO

Dmcbio; Boulder (CO); On-site; USD 125,000 - 155,000; Full time

Job summary

Dmcbio in Boulder, Colorado is seeking a Chemical Engineer to develop bench-scale processes for biologics and bioproducts. The role involves designing experiments, developing purification steps, and supporting tech transfer to manufacturing. Candidates should have a B.S. in a relevant field with 5+ years of relevant experience or 0–2 years for advanced degrees. Proficiency in experimental design tools like Python and strong technical writing skills are essential. The position includes a competitive salary range of $125,000 – $155,000 and opportunities for travel.

Qualifications

• 5+ years (B.S.) or 0–2 years (M.S./Ph.D.) of relevant experience in small molecule purifications or bioprocessing.
• Experience with scale-up/tech transfer and/or supporting manufacturing campaigns is preferred.

Responsibilities

• Bench-scale process development and optimization.
• Design, execute, and analyze experiments using purification unit operations.
• Support tech transfer to internal or external manufacturing sites.

Skills

Hands-on experience with chromatography

Experience with TFF/UFDF systems

Proficiency in experimental design and data analysis

Strong technical writing skills

Education

B.S. or higher in Chemical Engineering, Biochemical Engineering, Bioengineering, or a related discipline

Tools

Python

R

Excel

Job description

We are seeking a Chemical Engineer to join our Downstream Processing (DSP) Development team, focused on bench-scale process development for biologics/bioproducts and the translation of those processes to pilot and commercial manufacturing. You will design and execute experiments at bench scale (e.g., mL–L), develop robust purification steps (chromatography, filtration, precipitation, etc.), and work cross-functionally to transfer your process to industrial scale.

This role is ideal for an engineer who enjoys hands‑on lab work, rigorous data analysis, and solving scale‑up challenges with the end goal of commercializing processes at industrial scale. Traveling to partner sites for troubleshooting and overseeing tech‑transfer is likely.

The anticipated base salary for this role is $125,000 – $155,000 per year. Final compensation will be determined based on experience, skills, and geographic location, and may include bonus eligibility and a full benefits package.

Key Responsibilities

• Bench‑scale process development and optimization.
• Design, execute, and analyze experiments using purification unit operations (e.g., depth filtration, centrifugation, TFF/UFDF, chromatography, precipitation, etc.).
• Build methods and strategies to define scalable operating ranges, identify critical process parameters, and improve yield, purity, and throughput for purification unit operations.
• Support tech transfer to internal or external manufacturing sites, including documentation, protocols, and general transfer of process knowledge.
• Translate bench‑scale findings into continuous models to predict process flow rates, unit sizes, and overall process costs.
• Author and review development reports, batch records, protocols, and technical assessments to enable stage gates.
• Maintain high standards for data integrity, traceability, and reproducibility; ensure experiments and documentation align with internal quality systems and regulatory expectations.
• Collaborate with Upstream, Analytical, Quality, Regulatory, and Business teams to ensure end‑to‑end process performance and timeline execution.
• Communicate results clearly in team meetings and technical reviews; present recommendations backed by data and risk‑based reasoning.

Required Qualifications

• B.S. or higher in Chemical Engineering, Biochemical Engineering, Bioengineering, or a related discipline.
• 5+ years (B.S.) or 0–2 years (M.S./Ph.D.) of relevant experience in small molecule purifications, bioprocessing, or process development (industry or strong graduate/lab experience).
• Hands‑on experience with one or more of the following:
  • Chromatography (resin screening, column packing, scale‑down models)
  • TFF/UFDF systems (membrane selection, flux optimization, shear sensitivity, fouling mitigation)
  • Crystallization (solubility studies, process design, solid‑liquid‑separation methods)
  • Continuous process modeling (using advanced software packages or manually)
• Proficiency in experimental design and data analysis (Python, R, Excel, etc.)
• Strong technical writing skills

Preferred Qualifications

• Experience with scale‑up/tech transfer and/or supporting manufacturing campaigns.
• Knowledge of process characterization, risk assessment (FMEA), and concepts such as QbD.
• Availability to travel.
• Experience developing cost‑of‑goods (COGs) awareness and capacity/throughput assessments.
• Comfort with lab safety practices, equipment maintenance, and methodical troubleshooting.

How to Apply

Interested candidates should email their cover letter and resume to [e-mail], with the position title included in the subject line.

About DMC

DMC Biotechnologies is a U.S.-based biomanufacturer redefining how the world produces specialty chemicals and ingredients. Through precision fermentation and synthetic biology, DMC creates sustainable, bio‑based alternatives that reduce carbon emissions, enhance quality, and improve global supply chain resilience. The company’s proprietary Dynamic Metabolic Control™ platform enables predictable, scalable, and efficient fermentation processes that unlock a new era of low‑impact ingredient manufacturing.