Sr. Associate Scientist, R&D Chemistry, Peptidomimetic Purification

Regeneron Pharmaceuticals, Inc (USA); Hawthorne (CA); On-site; USD 80,000 - 110,000; Full time

Benefits offered by this job

Annual bonuses

401(k) company match

Health and wellness programs

Paid time off

Job summary

Regeneron Pharmaceuticals, Inc (USA) is seeking a talented Senior Associate Scientist to join their R&D Chemistry team in Hawthorne, California. This role will involve driving the purification of peptidomimetic and linker payloads for drug therapeutics, requiring extensive hands-on experience with HPLC and method troubleshooting.

The ideal candidate will possess a Bachelor's degree (Master’s preferred), at least 5 years of industry experience, and demonstrated success in purification techniques. Collaborative interactions with various teams are essential for success in this role. Regeneron offers a comprehensive benefits package.

Qualifications

• 5+ years of industry experience required.
• Extensive hands-on experience with HPLC purification.
• A track record of success in peptidomimetic purification.

Responsibilities

• Participate in day-to-day R&D Chemistry activities.
• Perform mass-triggered HPLC purification.
• Troubleshoot purification methods for high-throughput results.
• Identify strategies to enhance purification techniques.
• Engage in cross-functional meetings and collaborations.

Skills

HPLC purification/detection

Method troubleshooting

Collaborative work

Peptidomimetic purification

Experience with Waters/Agilent systems

Education

Bachelor’s degree in relevant field

Master’s degree preferred

Tools

Modern purification instrumentation

Mass-triggered collection systems

Job description

Sr. Associate Scientist (Peptidomimetic Purification), R&D Chemistry

Job Summary

We are currently seeking a lab-centric peptide purification chemist to join the R&D (Research & Development) Chemistry group. In this position, they will play a key role in Regeneron’s peptidomimetic antibody-conjugate drug discovery capabilities to enable seamless combination with the company’s existing expertise in biologics and novel genetic medicines. The candidate will drive the purification of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas. Cultural fit with the Regeneron cross‑functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative environment with other technology, biology and therapeutic area groups.

Responsibilities

• Act actively in the day‑to‑day activities of the R&D Chemistry Peptidomimetic purification team.
• Perform mass‑triggered HPLC purification of novel peptidomimetic drug modalities, using modern purification instrumentation/detection and techniques.
• Troubleshoot and optimize peptide purification methods and enable high‑throughput purification and isolation.
• Identify new strategies and technologies for peptidomimetic purification to improve on existing Regeneron techniques.
• Actively participate in departmental, cross‑functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic purification team.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.

Qualifications

• Bachelor’s degree required, Master’s degree preferred in peptide, peptidomimetic, small molecule purification.
• Minimum of 5 years of industry experience.
• Extensive hands‑on experience of the HPLC purification/detection and method troubleshooting of peptidomimetics.
• Hands‑on experience with Waters and/or Agilent purification systems preferred.
• Hands‑on experience with mass‑triggered collection preferred.
• Extensive experience running modern purification/isolation equipment and instrumentation.
• A track record of success in the field of either peptidomimetics or small molecules purification is required.
• Working collaboratively with both internal and external organizations (e.g., CROs) is essential.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

Equal Opportunity Statement

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.