Senior Associate Scientist, R&D Chemistry

Regeneron Pharmaceuticals, Inc (USA); Hawthorne (CA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Bonus plans

Comprehensive benefits

401(k) match

Job summary

Regeneron Pharmaceuticals, Inc. is seeking a Senior Associate Scientist in R&D Chemistry to support small‑molecule payloads and linker discovery for antibody‑drug conjugates. The role emphasizes retrosynthetic planning, multi‑step synthesis, and hands‑on execution with collaboration across biology and therapeutic areas.

The candidate will interpret spectroscopic data, design efficient synthetic routes, and contribute to SAR decisions within a collaborative, on‑site environment in California.

Qualifications

• MSc in synthetic organic chemistry or related field.
• 5–7 years of industry drug discovery experience with small molecules preferred.
• Familiarity with peptidomimetics or antibody‑targeted therapeutics is a plus.

Responsibilities

• Perform day‑to‑day laboratory activities, executing small‑molecule syntheses and characterization.
• Troubleshoot, analyze data, interpret results, and propose synthetic approaches to new targets.
• Discuss biological data and new targets within existing projects to address structure‑activity directions.
• Identify new strategies and technologies for synthetic execution of targets of interest.
• Interact with cross‑functional teams and your supervisor to drive project progress.
• Represent the R&D Chemistry group in cross‑functional meetings.

Skills

Small‑molecule synthesis

Retrosynthesis

Multistep synthesis

Spectroscopy

Education

MSc in synthetic organic chemistry

Tools

NMR

Mass spectrometry

Job description

Senior Associate Scientist, R&D Chemistry

We are currently seeking a synthetic organic chemist for the R&D (Research & Development) Chemistry group. In this position, you will support Regeneron’s small molecule antibody‑conjugate drug discovery capabilities, linking biologics and novel genetic medicines. You will enable in‑house laboratory‑based synthetic chemistry activities toward novel small‑molecule payloads and linkers for antibody‑drug conjugate therapeutics across oncology, metabolic disease/obesity, infectious diseases, immunology and inflammation, neuroscience, and ophthalmology. Cultural fit with Regeneron chemistry and cross‑functional teams is a priority.

The R&D Chemistry team is composed of synthetic organic, medicinal chemistry, and bioconjugation scientists who work in a highly collaborative environment with other technology, biology, and therapeutic area groups. Successful candidates will have a small‑molecule synthetic organic background and experience with retrosynthetic analysis, synthetic route design, and hands‑on execution of multistep synthetic protocols, including compound isolation and characterization. A firm understanding of modern organic synthesis strategies and techniques, and the ability to work independently while deploying an efficient approach to biologically active targets, will be essential. Ability to interpret spectroscopic data for small‑molecule structure assignment/confirmation is required. Knowledge of the latest synthetic methods used in antibody‑conjugate linker generation is a plus.

Day in the Life

• Perform day‑to‑day laboratory activities, executing small‑molecule syntheses and associated compound isolation and characterization.
• Troubleshoot, analyze data, interpret experimental results, and propose synthetic approaches to new targets.
• Discuss biological data and new targets within existing projects to address structure‑activity relationship directions.
• Identify new strategies and technologies best suited for synthetic execution of targets of interest.
• Work within the priorities set by cross‑functional teams and your supervisor.
• Ensure successful progression of the group’s technology and pipeline projects.
• Participate in departmental, cross‑functional meetings to contribute expertise and represent the R&D Chemistry group.
• Interact broadly and collaboratively with other Regeneron groups.

What Makes This Role a Good Fit

• You are passionate and enthusiastic about small‑molecule‑based, antibody‑targeted therapeutics and appreciate the challenges of synthetic chemistry and drug design.
• You enjoy developing solutions for synthesis and advancing structure‑activity relationships within medicinal chemistry drug discovery programs.
• You are comfortable working as part of a cross‑functional team.
• You want to be part of an organizational culture that supports growth and development of its people and capabilities.

Qualifications

• Have a M.Sc. in synthetic organic chemistry (or related), and familiarity with drug discovery processes and modern methods of synthetic organic and medicinal chemistry.
• Bonus: general understanding of biological target validation, ADME/PK, PD/efficacy, and how medicinal chemistry contributes to progress in these areas.
• A minimum of 5‑7 years of industry drug discovery experience with small molecules is required.
• Familiarity with peptidomimetics or antibody‑targeted therapeutics is a plus.

Work Environment

Many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (medical, dental, vision, life and disability), paid time off, and family support benefits.

For additional information about Regeneron benefits in the U.S. (https://careers.regeneron.com/en/working-at-regeneron/total-rewards/).

Equal Opportunity

Regeneron is an equal‑opportunity employer and all qualified applicants will receive consideration for employment without regard torace,color,religion or belief (or lack thereof),sex,sexual orientation,gender identity or expression,gender reassignment,marital or civil partnership status,civil status,pregnancy or parental status,age,disability,nationality,citizenship status,ethnic or national origin,membership of the Traveler community,familial status,genetic information,military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.