Associate Director, R&D Chemistry, Peptidomimetics

Regeneron Pharmaceuticals, Inc (USA); Hawthorne (CA); On-site; USD 130,000 - 160,000; Full time

Benefits offered by this job

Annual bonuses

401(k) company match

Health and wellness programs

Job summary

Regeneron Pharmaceuticals, Inc in Hawthorne, California, is seeking an Associate Director in R&D Chemistry to lead the peptidomimetic drug discovery efforts. This role demands an experienced leader capable of driving the generation of novel drug modalities and supervising the day-to-day activities of the Peptidomimetic group.

The ideal candidate will possess a Ph.D. and over 10 years of industry experience, emphasizing drug discovery and team leadership. The position offers a competitive benefits package and is located on-site.

Qualifications

• 10+ years of professional industry experience.
• Extensive experience with antibody-targeted peptidomimetic drug modalities.
• Expertise in SAR methods and biological modes of action.

Responsibilities

• Supervise the R&D Chemistry Peptidomimetic group and manage goals.
• Drive medicinal-chemistry-inspired generation of novel drug modalities.
• Participate in cross-functional meetings to represent the group's vision.

Skills

Peptide chemistry

Medicinal chemistry

Drug discovery

Team leadership

Education

Ph.D. in peptide or synthetic organic chemistry

Job description

Associate Director (Peptidomimetics), R&D Chemistry

We are currently seeking an established leader and drug hunter to expand Regeneron’s peptidomimetic antibody‑conjugate drug discovery capabilities. The Associate Director will drive discovery across diverse research areas and integrate with the company’s expertise in biologics and novel genetic medicines.

Key Responsibilities

• Directly supervise and manage the day‑to‑day activities of the R&D Chemistry Peptidomimetic group, establishing short‑term and long‑term goals.
• Communicate Regeneron senior leaders’ priorities, policies, and goals to the team.
• Drive medicinal‑chemistry‑inspired, SAR‑driven generation of novel peptidomimetic drug modalities using synthetically feasible and simplistically designed linkers to achieve optimal in vitro and in vivo properties of antibody‑conjugated therapeutics.
• Troubleshoot and optimize peptide potency and stability using standard peptide‑based principles (e.g., Ala scans), non‑natural amino acid incorporation, backbone modifications, and medicinal‑chemistry strategies guided by in vitro assays, plasma/serum stability, and metabolic ID data.
• Champion and lead the R&D Chemistry Peptidomimetic efforts on internal and external project teams, demonstrating the ability to multi‑task and manage parallel projects to contribute to Regeneron’s development pipeline.
• Identify new strategies and technologies—linker and payload design—to improve existing Regeneron platforms for peptidomimetic synthesis and bioconjugation.
• Participate in departmental, cross‑functional, and external meetings to contribute expertise and represent the group’s vision.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.

Qualifications

• Ph.D. in peptide, synthetic organic chemistry, or a related field.
• Minimum of 10years of professional industry experience.
• Extensive drug discovery experience with antibody‑targeted peptidomimetic drug modalities.
• Experience with the synthesis and manufacturing of peptidomimetic payloads and linkers.
• Expertise in modern medicinal‑chemistry structure‑activity relationship (SAR) methods.
• Deep understanding of biological modes of action (extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, toxicological evaluation).
• Track record of success in advancing peptidomimetics, small molecules, or antibody‑targeted therapeutics into the clinic and leading teams.

Location

This is an on‑site position located in our Hawthorne, NY facility. Occasional travel to the nearby Tarrytown facility may be required.

Benefits

Regeneron offers a competitive and comprehensive total rewards package, which may include annual bonuses, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits, paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.

EEO Statement

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.