Sr Associate Scientist - Conjugation Chemistry

Pfizer Inc; Pearl River, Northern (NY, KY); Hybrid; USD 69,000 - 114,000; Full time

Benefits offered by this job

Relocation assistance

Health benefits

Job summary

Pfizer’s Early Bioprocess Development team within Vaccine Research and Development seeks a Senior Associate Scientist to support conjugation process development for glycoconjugate vaccines. You will contribute to development, optimization, and scale-up, with careful documentation and compliance with cGMP/GLP guidelines.

The role requires a BS/MS in chemistry with 3–6 years of laboratory experience and a strong organic chemistry background, plus experience with analytical techniques such as HPLC,

Qualifications

• BS degree in Chemistry/Biochemistry or related discipline with 3–6 years lab experience or MS degree in Chemistry/Organic Chemistry or related discipline with 0–4 years of experience.
• Strong background in organic chemistry.
• Knowledge and ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical methods.
• Independently analyze and provide conclusions regarding experimental data generated.
• Strong verbal and written communication skills are required.
• Experience with documentation of laboratory notebook in an electronic format.
• Nice To Have: carbohydrate chemistry experience.
• Hands on experience with various analytical techniques such as HPLC, MALS, UV-Vis, NMR, and other routine lab instruments.
• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

Responsibilities

• Support the development, optimization and scale-up of glycoconjugate vaccine process development.
• In process analysis of glycoconjugates and intermediates.
• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, propose solution in discussion with other group members to advance objectives.
• Collaborate with colleagues within Vaccine Research and Development organization including Early Bioprocess fermentation, purification, analytical and formulation development groups.
• Participate in the technology transfer of developed process to clinical manufacturing site, both internally and externally, and provide the technical support as needed.
• Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.
• Perform other duties as assigned.

Skills

Organic chemistry

Data analysis

Communication skills

Notebook documentation

Instrument operation

Education

BS in Chemistry/Biochemistry

MS in Chemistry/Organic Chemistry

Tools

HPLC

MALS

NMR

UV-Vis

Job description

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best‑in‑class medicines to patients around the world.

Role Summary

As a Senior Associate Scientist in the Early Bioprocess Development within Pfizer Vaccine Research and Development, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include supporting the development and optimization of conjugation methods, purification, and analysis of intermediates and glycoconjugates using chemical and chromatographic methods. The individual will become a key contributor towards supporting the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

Role Responsibilities

Support the development, optimization and scale-up of glycoconjugate vaccine process development.

In process analysis of glycoconjugates and intermediates.

Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, propose solution in discussion with other group members to advance objectives.

Collaborate with colleagues within Vaccine Research and Development organization including Early Bioprocess fermentation, purification, analytical and formulation development groups.

Participate in the technology transfer of developed process to clinical manufacturing site, both internally and externally, and provide the technical support as needed.

Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.

Perform other duties as assigned.

Qualifications

Must have

BS degree in Chemistry/Biochemistry or related discipline with 3 to 6 years laboratory experience or MS degree in Chemistry/Organic Chemistry or related discipline with 0 to 4 years of experience.

Strong background in organic chemistry is required.

Knowledge and ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical methods.

Independently analyze and provide conclusions regarding experimental data generated.

Strong verbal and written communication skills are required.

Experience with documentation of laboratory notebook in an electronic format.

Nice To Have

Experience in carbohydrate chemistry

Hands on experience with various analytical techniques such as HPLC, MALS, UV-Vis, NMR, and other routine lab instruments.

Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

Other Work Details

Work Assignment: On Site

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best‑in‑class medicines to patients around the world.

Role Summary

As a Senior Associate Scientist in the Early Bioprocess Development within Pfizer Vaccine Research and Development, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include supporting the development and optimization of conjugation methods, purification, and analysis of intermediates and glycoconjugates using chemical and chromatographic methods. The individual will become a key contributor towards supporting the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

Role Responsibilities

• Support the development, optimization and scale-up of glycoconjugate vaccine process development.

• In process analysis of glycoconjugates and intermediates.

• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, propose solution in discussion with other group members to advance objectives.

• Collaborate with colleagues within Vaccine Research and Development organization including Early Bioprocess fermentation, purification, analytical and formulation development groups.

• Participate in the technology transfer of developed process to clinical manufacturing site, both internally and externally, and provide the technical support as needed.

• Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.

• Perform other duties as assigned.

Qualifications

Must have

• BS degree in Chemistry/Biochemistry or related discipline with 3 to 6 years laboratory experience or MS degree in Chemistry/Organic Chemistry or related discipline with 0 to 4 years of experience.

• Strong background in organic chemistry is required.

• Knowledge and ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical methods.

• Independently analyze and provide conclusions regarding experimental data generated.

• Strong verbal and written communication skills are required.

• Experience with documentation of laboratory notebook in an electronic format.

Nice To Have

• Experience in carbohydrate chemistry

• Hands on experience with various analytical techniques such as HPLC, MALS, UV-Vis, NMR, and other routine lab instruments.

• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

Other Work Details

• Work Assignment: On Site

• Relocation support available

• Work Location Assignment:On Premise

The annual base salary for this position ranges from $68,600.00 to $114,300.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [e-mail] . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers .