Sr Associate Scientist - Conjugation Chemistry

Pfizer; Pearl River (LA); On-site; USD 69,000 - 114,000; Full time

Benefits offered by this job

Relocation assistance

Job summary

Pfizer is seeking a Senior Associate Scientist in Early Bioprocess Development to advance conjugation and purification methods for glycoconjugate vaccines. You will join a large, quality-focused team responsible for early development and scale-up, documentation, and data presentation in a cGMP/GLP environment.

The role emphasizes developing robust processes, collaboration with cross-disciplinary groups, data analysis, and timely reporting, with on-site work and relocation support if needed.

Qualifications

• BS or MS with relevant laboratory experience in organic chemistry or related discipline.
• Experience with analytical methods and instrument operation.
• Ability to document results in electronic notebooks with attention to compliance.

Responsibilities

• Support the development and scale-up of glycoconjugate vaccine processes.
• Perform in-process analysis of glycoconjugates and intermediates.
• Evaluate and propose improvements to robustness and scalability of operations.
• Collaborate with Vaccine R&D groups including fermentation, purification, analytics, and formulation teams.
• Assist technology transfer to clinical manufacturing sites and provide technical support as needed.
• Maintain timely, compliant documentation and prepare technical reports.

Skills

Strong communication

Data interpretation

Electronic notebook documentation

Analytical problem solving

Education

BS in Chemistry/Biochemistry or related

MS in Chemistry/Organic Chemistry or related

Tools

HPLC

MALS

NMR

Job description

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

Role Summary

As a Senior Associate Scientist in the Early Bioprocess Development within Pfizer Vaccine Research and Development, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include supporting the development and optimization of conjugation methods, purification, and analysis of intermediates and glycoconjugates using chemical and chromatographic methods. The individual will become a key contributor towards supporting the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

Role Responsibilities

• Support the development, optimization and scale-up of glycoconjugate vaccine process development.
• In process analysis of glycoconjugates and intermediates.
• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, propose solution in discussion with other group members to advance objectives.
• Collaborate with colleagues within Vaccine Research and Development organization including Early Bioprocess fermentation, purification, analytical and formulation development groups.
• Participate in the technology transfer of developed process to clinical manufacturing site, both internally and externally, and provide the technical support as needed.
• Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.
• Perform other duties as assigned.

Qualifications

Must have

• BS degree in Chemistry/Biochemistry or related discipline with 3 to 6 years laboratory experience or MS degree in Chemistry/Organic Chemistry or related discipline with 0 to 4 years of experience.
• Strong background in organic chemistry is required.
• Knowledge and ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical methods.
• Independently analyze and provide conclusions regarding experimental data generated.
• Strong verbal and written communication skills are required.
• Experience with documentation of laboratory notebook in an electronic format.

Nice To Have

• Experience in carbohydrate chemistry
• Hands on experience with various analytical techniques such as HPLC, MALS, UV-Vis, NMR, and other routine lab instruments.
• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

Other Work Details

• Work Assignment: On Site
• Relocation support available
• Work Location Assignment:On Premise

The annual base salary for this position ranges from $68,600.00 to $114,300.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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Research and Development