Sr. Assoc. Scientist

Regeneron; Hawthorne (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

Regeneron Genetic Medicines in Hawthorne, CA is seeking a Senior Associate Scientist to advance oligomer and oligonucleotide synthesis, purification, and analytical characterization. You will run solid-phase synthesis on automated platforms, prepare modified RNA-related materials, and generate high-quality data to guide platform R&D.

The role sits at the interface of synthetic chemistry, analytics, and RNA therapeutics, requiring strong experimental records and collaboration with chemists,

Qualifications

• BS in chemistry, biochemistry, chemical biology, biology, or a related scientific discipline; Masters preferred.
• Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience.
• Hands-on experience with solid-phase organic synthesis, particularly oligonucleotide/oligomer workflows.
• Nice to have familiarity with automated synthesis platforms such as MerMade or OligoSynt; purification and analytics experience (SEC, AEX, RP-HPLC or RPIP-HPLC, LC-MS).

Responsibilities

• Execute solid-phase oligomer and oligonucleotide synthesis on automated platforms; prepare reagents and set cycles.
• Support synthesis of RNA-related constructs of varied lengths and modifications for discovery and platform development.
• Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and efficiency.
• Purify synthesized oligomers using SEC, AEX, RP-HPLC, and ion-pair RP methods.
• Characterize purified materials using LC-MS, HPLC/UPLC, UV-Vis, and orthogonal techniques.
• Analyze results, summarize findings, and recommend next steps to guide chemistry design.
• Maintain accurate experimental records and ensure safety and documentation standards.
• Collaborate with chemists, biologists, and project teams to advance RGM Chemistry objectives.

Skills

Oligonucleotide Synthesis

Solid-Phase Synthesis

Analytical Characterization

LC-MS / HPLC

Automation Platforms

Education

Bachelor's degree in Chemistry

Master's degree preferred

Tools

MerMade

OligoSynt

Job description

At Regeneron Genetic Medicines, we are driven by a mission to transform the treatment of serious diseases through groundbreaking genetic therapies. Our team is at the forefront of innovation, applying cutting-edge science to improve patient outcomes and redefine the future of medicine.

We are seeking a highly motivated and detail-oriented Senior Associate Scientist to join the RGM R&D Chemistry team with a focus on oligomer and oligonucleotide synthesis, purification, and analytical characterization. The successful candidate will support the design and execution of solid-phase synthesis workflows, contribute to the preparation of modified RNA-related materials, and generate high-quality analytical data to guide platform research and development. This role offers an opportunity to work at the interface of synthetic chemistry, analytical characterization, and RNA therapeutic innovation while contributing to programs that may meaningfully advance future medicines.

What You'll Do:

• Execute solid-phase oligomer and oligonucleotide synthesis using automated synthesis platforms, including preparation of reagents, setup of synthesis cycles, incorporation of standard and chemically modified amidites, and on-bead or post-synthetic modifications as needed.
• Support synthesis of RNA-related constructs of varied lengths, formats, and chemical modification to enable discovery, platform development, and cross-functional program needs.
• Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency.
• Perform purification of synthesized oligomers using appropriate chromatographic techniques, including size-exclusion, anion-exchange, reverse-phase, and ion-pair reverse-phase methods.
• Characterize purified materials using analytical methods such as LC-MS, HPLC/UPLC, UV-Vis, and other orthogonal techniques to confirm identity, purity, concentration, and product quality.
• Analyze and interpret experimental results, summarize findings clearly, and recommend next steps to support iterative chemistry design and platform advancement.
• Maintain accurate, complete, and timely experimental records in accordance with laboratory standards, safety expectations, and internal documentation practices.
• Support routine operation, maintenance, troubleshooting, and inventory management for key synthesis and analytical instrumentation, reagents, and laboratory supplies.
• Collaborate effectively with chemists, biologists, analytical scientists, and project teams to advance RGM Chemistry objectives and communicate technical progress in team discussions.

Let's Find Out If We're a Fit:

• B.S. in chemistry, biochemistry, chemical biology, biology, or a related scientific discipline is required; Masters degree is preferred
• Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience required.
• Hands-on experience with solid-phase organic synthesis is preferred, particularly oligonucleotide, peptide, oligomer, or related polymer/biopolymer synthesis workflows.
• Nice to have - familiarity with automated synthesis platforms such as MerMade, OligoSynt, or comparable oligonucleotide/oligomer synthesizers is highly desirable. Experience with purification and analytical characterization methods, including SEC, AEX, RP-HPLC or RPIP-HPLC, and LC-MS.

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness pr