Sr. Assoc. Scientist

Regeneron Pharmaceuticals, Inc (USA); Hawthorne (CA); On-site; USD 80,000 - 131,000; Full time

Benefits offered by this job

Bonus programs

Equity awards

Pension or retirement benefits

401(k) company match

Health and wellness programs

Fitness centers

Insurance benefits

Paid time off

Family support benefits

Job summary

Regeneron Genetics Medicines seeks a Senior Associate Scientist to advance oligomer and oligonucleotide synthesis, purification, and analytics. The role covers solid‑phase synthesis workflows, preparation of modified RNA materials, and generation of high‑quality data to guide platform R&D.

You will work at the interface of synthetic chemistry and RNA therapeutics with cross‑functional teams. Required BS in chemistry/biochemistry/related field; 5+ years post‑BS or 3+ years post‑MS; experience

Qualifications

• BS in chemistry, biochemistry, chemical biology, biology, or related discipline; Masters preferred.
• Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience.
• Hands-on experience with solid-phase organic synthesis, especially oligonucleotide/oligomer workflows.

Responsibilities

• Execute solid-phase oligomer and oligonucleotide synthesis using automated platforms.
• Purify synthesized oligomers using SEC, AEX, RP-HPLC or RPIP-HPLC, and LC‑MS/UV methods.
• Characterize materials with LC‑MS, HPLC/UPLC, UV‑Vis; confirm identity and purity.
• Maintain thorough experimental records per lab standards and safety.
• Collaborate with chemists, biologists, and analytics teams to advance projects.

Skills

Solid-phase synthesis

Oligonucleotide synthesis

Analytical characterization

LC-MS

HPLC/UPLC

UV-Vis

Data interpretation

Cross-functional collaboration

Education

B.S. in chemistry/biochemistry/chemical biology/biology or related

M.S. preferred

Tools

MerMade

OligoSynt

Job description

At Regeneron Genetic Medicines, we are driven by a mission to transform the treatment of serious diseases through groundbreaking genetic therapies. Our team is at the forefront of innovation, applying cutting‑edge science to improve patient outcomes and redefine the future of medicine. We are seeking a highly motivated and detail‑oriented Senior Associate Scientist to join the RGM R&D Chemistry team with a focus on oligomer and oligonucleotide synthesis, purification, and analytical characterization. The successful candidate will support the design and execution of solid‑phase synthesis workflows, contribute to the preparation of modified RNA‑related materials, and generate high‑quality analytical data to guide platform research and development. This role offers an opportunity to work at the interface of synthetic chemistry, analytical characterization, and RNA therapeutic innovation while contributing to programs that may meaningfully advance future medicines.

What You'll Do

Sr. Associate Scientist focused on oligomer synthesis and characterization: Execute solid‑phase oligomer and oligonucleotide synthesis using automated synthesis platforms, including preparation of reagents, setup of synthesis cycles, incorporation of standard and chemically modified amidites, and on‑bead or post‑synthetic modifications as needed. Support synthesis of RNA‑related constructs of varied lengths, formats, and chemical modification to enable discovery, platform development, and cross‑functional program needs. Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency. Perform purification of synthesized oligomers using appropriate chromatographic techniques, including size‑exclusion, anion‑exchange, reverse‑phase, and ion‑pair reverse‑phase methods. Characterize purified materials using analytical methods such as LC‑MS, HPLC/UPLC, UV‑Vis, and other orthogonal techniques to confirm identity, purity, concentration, and product quality. Analyze and interpret experimental results, summarize findings clearly, and recommend next steps to support iterative chemistry design and platform advancement. Maintain accurate, complete, and timely experimental records in accordance with laboratory standards, safety expectations, and internal documentation practices. Support routine operation, maintenance, troubleshooting, and inventory management for key synthesis and analytical instrumentation, reagents, and laboratory supplies. Collaborate effectively with chemists, biologists, analytical scientists, and project teams to advance RGM Chemistry objectives and communicate technical progress in team discussions.

Let's Find Out If We're a Fit

B.S. in chemistry, biochemistry, chemical biology, biology, or a related scientific discipline is required; Masters degree is preferred. Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience required. Hands‑on experience with solid‑phase organic synthesis is preferred, particularly oligonucleotide, peptide, oligomer, or related polymer/biopolymer synthesis workflows. Nice to have - familiarity with automated synthesis platforms such as MerMade, OligoSynt, or comparable oligonucleotide/oligomer synthesizers is highly desirable. Experience with purification and analytical characterization methods, including SEC, AEX, RP‑HPLC or RPIP‑HPLC, and LC‑MS.

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.

If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually) $80,300.00 - $131,100.00

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician‑scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA‑approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.