Spring Co-Op 2027, In Silico Modeling

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 45,000 - 69,000; Full time

Benefits offered by this job

Gym access

Commuter benefits

Free meals

Career development

Social events

Location-specific perks

National Intern Day recognition

Job summary

Vertex Pharmaceuticals LLC is seeking a highly motivated Co‑Op in In Silico Modeling to join our group. You will work on developing tools to understand structure–function relationships for biologics and contribute to meaningful projects in a biopharmaceutical setting.

The program focuses on advanced degree students, with exposure to workflows, modeling, and collaboration in a fast-paced environment. It is a 6‑month, full‑time co‑op beginning January 2027 in the United States.

Qualifications

• PhD candidate or Master’s student in Computational Sciences, Biology, Chemistry or related field.
• Hands-on experience with in silico modeling and protein/antibody structure prediction.
• Experience with molecular dynamics and protein–protein interactions.
• Able to adapt work schedule and collaborate in a multidisciplinary team.
• Strong communication and teamwork abilities.

Responsibilities

• Build workflows for protein structure prediction and structure–function analysis.
• Use molecular dynamics to evaluate interactions and macroscopic properties like viscosity.
• Incorporate experimental data to refine models and workflows.
• Assess Vertex pipeline molecules with established workflows as needed.
• Document progress with analytical development reports and lab notes.

Skills

In silico modeling

Protein structure prediction

Molecular dynamics

Team collaboration

Communication skills

Education

PhD candidate

Master's student

Tools

MOE

Maestro/Schrodinger

Desmond

GROMACS

NAMD/VMD

Job description

Kickstart Your Career at Vertex!

Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co‑op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab.

Why Vertex?

• Real Projects: You'll work on assignments that make a real impact, not just busy work.
• Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer‑term career.
• Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing.
• Inclusive Culture: Collaboration and inclusion are embedded in everything we do.
• Career Launchpad: Build skills, explore career paths, and get guidance for your future career.

Your Impact

The Vertex In Silico Modeling Co‑Op is a 6‑month experiential training program for students currently working towards an advanced degree in Computational Chemistry, Computational Biology or other related fields. If you are passionate, collaborative, and growth‑minded, a co‑op at Vertex will help you gain meaningful experience in our Analytical Development functional areas and serve as a launchpad for your career.

The application deadline for this co‑op is November 15th. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the application deadline.

What you will be doing:

We are seeking a highly motivated Co‑Op to join our group, focusing on developing in silico modeling tools to understand structure function relationship for biologics therapeutics. As a Co‑Op at Vertex Pharmaceuticals, you will have the unique opportunity to gain practical experience and contribute to meaningful projects.

This co‑op role is designed to provide you with exposure to various aspects of therapeutics development, helping you build valuable skills while working alongside experienced professionals in a dynamic and innovative biopharmaceutical environment.

Key Responsibilities:

• Build workflows for protein structure prediction and contribute on protein structure‑function relationship understanding
• Utilize molecular dynamics simulation tools to evaluate protein‑protein and protein‑excipient interactions, predict macroscopic properties such as aggregation propensity, protein solution viscosity, and
• Leverage experimental data to further refine the model and workflows
• Evaluate Vertex pipeline molecules with established workflows as needed
• Report on project progress, write analytical development protocols and method development reports.
• Maintain excellent written documentation (e.g. lab notebook and test forms)

Qualifications:

• Ph.D. candidate or highly experienced Master's student studying, Computational Sciences, Biology, Chemistry or a related field
• Hands‑on experience with in silico modeling and structural prediction of proteins and antibodies
• Hands‑on experience with molecular dynamics simulation and understanding of protein‑ligand and protein‑protein interaction
• Ability to adapt and be flexible with respect to working schedule
• Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team
• Familiar with modeling tools such as: MOE, Maestro/Schrodinger, Desmond, GROMACS, NAMD/VMD

Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships/co‑ops or entry level roles within this part of the organization.

You must be enrolled in an advanced degree program if graduating before May 2027

You must be available to work full‑time, 40 hours per week from January - July 2027

Program Details:

• Full‑time, paid co‑op $33.00 - 50.00 USD/hour
• Program Dates: January - July 2027
• Application Deadline: November 15th, 2026

At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well‑being resources are designed to support you.

• Free 24/7 onsite gym access and free access to group exercise classes
• Subsidized commuter benefits- transit and parking
• Provided meals-free breakfast daily!
• Career development opportunities and events, including C Suite engagement
• Social events-both intern-only and company‑wide
• Location‑specific perks and extras!
• Recognition of National Intern Day