Spring Co-Op 2027, Silico Modeling

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 45,000 - 69,000; Full time

Benefits offered by this job

Free onsite gym 24/7

Free meals daily at site

Subsidized commuter benefits

Career development opportunities

Company-wide and intern events

Job summary

Vertex Pharmaceuticals LLC in Boston seeks a highly motivated Co-Op for a 6-month period beginning January 2027. You will develop in silico modeling tools to understand structure-function relationships for biologics and contribute to predictive workflows in a fast-paced biopharmaceutical setting.

The role offers full-time hours, competitive hourly pay, and exposure to analytical development projects across configurations.

Qualifications

• Ph.D. candidate or highly experienced Master's student.
• Hands-on experience with in silico modeling and structural prediction of proteins and antibodies.
• Hands-on experience with molecular dynamics simulation and understanding of protein-ligand and protein-protein interaction.
• Adaptable to changing schedules and team environments.
• Excellent communication skills and ability to collaborate across disciplines.
• Authorized to work in the United States; sponsorship not offered.
• Must be enrolled in an advanced degree program if graduating before May 2027.
• Available to work full-time, 40 hours/week from January–July 2027.

Responsibilities

• Build workflows for protein structure prediction.
• Utilize molecular dynamics tools to assess interactions and properties.
• Refine models using experimental data and existing workflows.
• Evaluate pipeline molecules with established workflows.
• Report progress and write development protocols and reports.
• Maintain thorough lab notebooks and documentation.

Skills

In silico modeling

Structural prediction

Molecular dynamics

Protein-protein interaction

Protein-ligand interaction

Communication

Team collaboration

Flexibility

Education

Ph.D. candidate

Master's student

Tools

MOE

Maestro/Schrodinger

Desmond

GROMACS

NAMD/VMD

Job description

## Spring Co-Op 2027, Silico ModelingApply: Boston, MA: Full time: Posted Today: End Date: November 15, 2026 (30 days left to apply): REQ-30502**Job Description****Kickstart Your Career at Vertex!** Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab.**Why Vertex?*** **Real Projects:**You’ll work on assignments that make a real impact, not just busy work.* **Mentorship & Networking:**Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career.* **Flexible & Supportive:**We offer flexible work options with Flex @ Vertex and prioritize your wellbeing.* **Inclusive Culture:**Collaboration and inclusion are embedded in everything we do.* **Career Launchpad:**Build skills, explore career paths, and get guidance for your future career.**Your Impact**The Vertex Silico Modeling Co-Op is a 6-month experiential training program for students currently working towards an advanced degree in Computational Chemistry, Computational Biology or other related fields. If you are passionate, collaborative, and growth-minded, a co-op at Vertex will help you gain meaningful experience in our Analytical Development functional areas and serve as a launchpad for your career.*The application deadline for this co-op is November 15th. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the application deadline.***Ready to apply? Submit your application and let’s turn possibilities into reality!****What you will be doing:** We are seeking a highly motivated Co-Op to join our group, focusing on developing in silico modeling tools to understand structure function relationship for biologics therapeutics. As a Co-Op at Vertex Pharmaceuticals, you will have the unique opportunity to gain practical experience and contribute to meaningful projects. This co-op role is designed to provide you with exposure to various aspects of therapeutics development, helping you build valuable skills while working alongside experienced professionals in a dynamic and innovative biopharmaceutical environment.**Key Responsibilities:*** Build workflows for protein structure prediction and contribute on protein structure-function relationship understanding* Utilize molecular dynamics simulation tools to evaluate protein-protein and protein-excipient interactions, predict macroscopic properties such as aggregation propensity, protein solution viscosity, and* Leverage experimental data to further refine the model and workflows* Evaluate Vertex pipeline molecules with established workflows as needed* Report on project progress, write analytical development protocols and method development reports.* Maintain excellent written documentation (e.g. lab notebook and test forms)**Qualifications:*** Ph.D. candidate or highly experienced Master's student.* Hands-on experience with in silico modeling and structural prediction of proteins and antibodies* Hands-on experience with molecular dynamics simulation and understanding of protein-ligand and protein-protein interaction* Ability to adapt and be flexible with respect to working schedule* Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team* Familiar with modeling tools such as: MOE, Maestro/Schrodinger, Desmond, GROMACS, NAMD/VMD* Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships/co-ops or entry level roles within this part of the organization.* You must be enrolled in an advanced degree program if graduating before May 2027* You must be available to work full-time, 40 hours per week from January – July 2027**Program Details:** * Full-time, paid co-op $33.00 – 50.00 USD/hour* Program Dates: January – July 2027* Application Deadline: November 15th, 2026**At Vertex, we believe that when you feel your best, you can perform at your best. That’s why our US benefits and global well-being resources are designed to support you.**• Free 24/7 onsite gym access and free access to group exercise classes• Subsidized commuter benefits- transit and parking• Provided meals—free breakfast daily!• Career development opportunities and events, including C Suite engagement• Social events—both intern-only and company-wide• Location-specific perks and extras!• Recognition of National Intern Day **Our Ways of Working** Flex Designation: On-Site - BostonFlex Eligibility Status: On-Site: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.*This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer.*