Site Operations & Strategy Execution Director

Denali Therapeutics Inc; Salt Lake City (UT); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

401k

Healthcare coverage

Employee stock purchase plan

Job summary

Denali Therapeutics Inc, based in Salt Lake City, seeks a Director of Site Operations & Strategic Execution to lead the SLC operating model, governance processes, and performance metrics across manufacturing, quality, supply chain, and technical operations. The role requires balancing strategic thinking with hands-on execution in a fast-paced biopharma setting.

The ideal candidate will drive operational readiness, support strategic initiatives, and ensure scalable operations while partnering

Qualifications

• Bachelor’s degree in Engineering, Life Sciences, Operations, Supply Chain, Business or related field is typically required.
• Advanced degree is preferred.
• Demonstrated experience leading complex cross-functional operational initiatives in a GMP-regulated environment.

Responsibilities

• Lead and continuously improve the SLC Site Operating Model, including governance, processes, decision frameworks, and cross-functional execution governance.
• Partner with Site Leadership and enterprise teams to align site execution with strategic priorities across manufacturing, quality, supply chain, engineering, and technical operations.
• Establish and manage governance forums, business reviews, metrics, dashboards, and reporting processes to enhance visibility, accountability, risk management, and data-driven decision-making.
• Lead strategic initiatives and continuous improvement efforts that strengthen operational readiness, scalability, organizational agility, and long-term commercial growth capabilities.
• Facilitate cross-functional coordination, resource planning and prioritization, and issue resolution while coaching and developing project leadership and operational execution capabilities.

Skills

Cross-functional leadership

Strategic thinking

Executive communication

Change management

GMP knowledge

Education

Bachelor’s degree in Engineering, Life Sciences, Operations, Supply Chain, or related field

Advanced degree preferred

Job description

Denali Therapeutics Inc, based in Salt Lake City, seeks a Director of Site Operations & Strategic Execution to lead the SLC operating model, governance processes, and performance metrics across manufacturing, quality, supply chain, and technical operations. The role requires balancing strategic thinking with hands-on execution in a fast-paced biopharma setting.

The ideal candidate will drive operational readiness, support strategic initiatives, and ensure scalable operations while partnering