Senior Vaccine Drug Product Development Scientist

AstraZeneca; Gaithersburg (MD); On-site; USD 138,000 - 208,000; Full time

Job summary

AstraZeneca in Gaithersburg, MD seeks an Associate Principal Scientist to lead vaccine drug product formulation development for multi‑antigen/adjuvant products and other vaccine modalities. You will drive strategies, influence CMC decisions, and lead cross‑functional teams through early formulation to pivotal clinical development.

You will guide analytical strategy, oversee GMP readiness, and manage external partnerships while ensuring robust, scalable processes and strong regulatory support.

Qualifications

• Education in Biochemistry, Chemistry, Immunology, Pharmaceutics or related field.
• Hands-on vaccine formulation and adjuvant experience across clinical phases.
• GMP manufacturing, tech transfer to CMOs/CDMOs, and clinical supply experience.

Responsibilities

• Lead formulation development for multi‑antigen/adjuvant products and vaccine modalities.
• Define studies, control strategies, and support antigen–adjuvant interactions.
• Partner with Analytical Sciences to define methods and data expectations.
• Drive process design, scale‑up, and GMP manufacturing readiness.
• Oversee technology transfer and regulatory documentation for submissions.
• Provide scientific leadership and mentorship across functions.

Skills

Vaccine Formulation

Adjuvant Systems

Cross-functional Leadership

CMC Strategy

Regulatory Submissions

Education

BS/MS/PhD in Biochemistry/Chemistry/Immunology/Pharmaceutics

Tools

DLS

Chromatography

Mass Spectrometry

Spectroscopy

Job description

AstraZeneca in Gaithersburg, MD seeks an Associate Principal Scientist to lead vaccine drug product formulation development for multi‑antigen/adjuvant products and other vaccine modalities. You will drive strategies, influence CMC decisions, and lead cross‑functional teams through early formulation to pivotal clinical development.

You will guide analytical strategy, oversee GMP readiness, and manage external partnerships while ensuring robust, scalable processes and strong regulatory support.