Senior Upstream Biologics Process Scientist

Merck; New Jersey; Sur place; USD 120 000 - 180 000; Plein temps

Résumé du poste

Merck is seeking an Associate Principal Scientist in Upstream Process Development to lead mammalian cell culture process development for clinical and commercial programs. You will design, optimize, and transfer scalable processes to manufacturing, partnering with Discovery, Downstream, and Manufacturing teams.

A strong track record in CHO biology, DoE, and cross-functional collaboration is essential. You will mentor junior staff, publish results, and contribute to regulatory submissions while

Qualifications

• Ph.D. with 4+ years in chemical engineering, Bioengineering, Biological Engineering, or related field.
• Hands-on mammalian cell culture and fed-batch processes for recombinant protein production.
• Strong knowledge of CHO cell biology, metabolism, and large-scale production principles.
• Experience with DoE and multivariate data analysis; proficient in SIMCA and JMP.
• Proven upstream process development accomplishments and publications/presentations.

Responsabilités

• Leads upstream process development for first-in-human and commercial processes; develops high-yield, robust, scalable cell culture processes.
• Conducts process development, characterization, and regulatory filing activities to support PPQ and BLA.
• Collaborates across Discovery, Cell Line, Downstream, Analytical Sciences, and Manufacturing for integrated processes.
• Advances platform processes through improvement initiatives to boost efficiency and cut costs.
• Engages with academia, industry, and vendors to drive new process technologies; publishes and patents as appropriate.

Connaissances

Mammalian cell culture

CHO biology

Design of Experiment

Multivariate data analysis

Scientific publications

Collaboration

Communication skills

Problem solving

Bioreactors

Bioreactor simulation

Formation

Ph.D. with 4+ years' experience

Master's with 8+ years' experience

Outils

SIMCA

JMP

Description du poste

Merck is seeking an Associate Principal Scientist in Upstream Process Development to lead mammalian cell culture process development for clinical and commercial programs. You will design, optimize, and transfer scalable processes to manufacturing, partnering with Discovery, Downstream, and Manufacturing teams.

A strong track record in CHO biology, DoE, and cross-functional collaboration is essential. You will mentor junior staff, publish results, and contribute to regulatory submissions while