Senior Translational PK/PD Modeler

Regeneron Pharmaceuticals, Inc.; Village of Tarrytown (NY); Vor Ort; USD 151.000 - 246.000; Vollzeit

Zusammenfassung

Regeneron Pharmaceuticals, Inc. seeks a Principal Scientist of Translational PK/PD Modeling in Tarrytown, NY. The role develops quantitative PK/PD models to inform target biology and dose selection for early clinical programs.

The candidate will lead modeling efforts, mentor others, present work at scientific venues, and collaborate across Clinical Pharmacology, Quantitative Pharmacology and R&D to advance diverse therapeutic modalities.

Qualifikationen

• Ph.D. and 4+ years of experience in PK/PD modeling and simulation.
• Pharmaceutical industry experience required.
• Experience with modeling platforms (Monolix, Phoenix NLME, NONMEM, ADAPT, MATLAB, SimBiology).
• Strong PK/PD theory and practical foundation (non-compartmental, compartmental, PBPK).
• Ability to learn new biological areas to model new modalities.
• Familiarity with monoclonal/bispecific antibodies, gene therapy, CAR-T, siRNA products.

Aufgaben

• Develops and implements quantitative PK/PD models for preclinical-to-early clinical translation.
• Contributes to strategic direction of modeling and simulation sciences.
• Designs and interprets in vitro/in vivo quantitative pharmacology studies.
• Collaborates with Clinical Pharmacology, Quantitative Pharmacology and R&D teams.

Kenntnisse

PK/PD modeling

Mechanistic modeling

Preclinical-to-clinical translation

Quantitative pharmacology

Ausbildung

PhD in pharmacokinetics/pharmaceutical sciences/engineering

MS in related field (with 6+ years)

Tools

Monolix

Phoenix NLME

NONMEM

ADAPT

MATLAB

SimBiology

Jobbeschreibung

Regeneron Pharmaceuticals, Inc. seeks a Principal Scientist of Translational PK/PD Modeling in Tarrytown, NY. The role develops quantitative PK/PD models to inform target biology and dose selection for early clinical programs.

The candidate will lead modeling efforts, mentor others, present work at scientific venues, and collaborate across Clinical Pharmacology, Quantitative Pharmacology and R&D to advance diverse therapeutic modalities.