Principal Scientist, Translational PK/PD Modeling

Regeneron Pharmaceuticals; Tarrytown (GA); On-site; USD 151,000 - 246,000; Full time

Job summary

Regeneron Pharmaceuticals seeks a Principal Scientist of Translational PK/PD Modeling to develop quantitative and mechanistic PK/PD models guiding preclinical-to-early clinical translation and first-in-human dose selection. The role informs target biology and therapeutic modality optimization within an on-site team in our Tarrytown, NY office.

You will lead modeling and simulation efforts, collaborate with Clinical Pharmacology, and contribute to study design while mentoring others and

Qualifications

• Ph.D. with 4+ years of PK/PD modeling experience or MS with 6+ years in pharma/biotech.
• Experience applying quantitative and mechanism-based PK/PD modeling to therapeutics.
• Industry experience in pharmacometrics or related field.

Responsibilities

• Develops quantitative and mechanistic PK/PD models for preclinical to early clinical translation.
• Contributes to advancing modeling and simulation sciences strategy.
• Supports project teams with in vitro/in vivo quantitative pharmacology studies.
• Summarizes analyses for multidisciplinary teams and communicates findings.
• Keeps up with emerging literature and collaborates with Clinical Pharmacology and R&D teams.
• Shares learnings and develops best practices across disease areas.
• Mentors others and presents work at meetings and journals.
• Travels as needed to collaborate with teams.

Skills

Quantitative PK/PD modeling

Translational pharmacology

Modeling strategy

Education

Ph.D. in pharmacokinetics/pharmaceutical sciences/engineering

M.S. in related discipline

Tools

Monolix

Phoenix NLME

NONMEM

MATLAB/SimBiology

Job description

Build Our Future Together

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Prinicpal Scientist of Translational PK/PD Modeling to develop and implement quantitative and mechanistic PK/PD models to aid in the understanding of target biology, therapeutic modality selection/optimization, and contributes to early clinical trial dose selection and/or design and advancement and strategic direction of modeling and simulation sciences.

When & Where:

This role will be based in our Tarrytown, NY office and is expected to be on-site four days per week.

Discover Your Role:

• Independently develops and implements quantitative and mechanistic mathematical PK/PD models that inform preclinical-to-early clinical translation, including human efficacious dose predictions and first-in-human dose selection.
• Actively contributes to the advancement and strategic direction of modeling and simulation sciences
• Provides expert support to pre-clinical PK/PD project representatives and R&D project teams to design, execute and interpret in vitro and in vivo quantitative pharmacology studies. This included working with the Research PK group to optimize use of mouse PK data to inform translation to nonhuman primate and human PK.
• Effectively integrates and summarizes modeling and simulation analyses into useable information for multidisciplinary project teams.
• Remains apprised of emerging science and literature, and effectively collaborates with subject matter experts in Clinical Pharmacology, Quantitative Pharmacology and R&D to advance modeling and simulation sciences.
• Shares learnings and develops best practices across disease areas and therapeutic approaches.
• Committed to sharing technical expertise and the development / mentoring of others.
• Presents work at internal/external scientific meetings and publishes work in scientific journals

This Role Requires

• Ph.D. and 4+ years of experience, or M.S. and 6+ years of experience in pharmacokinetics, pharmaceutical sciences, engineering, applied mathematics or related disciplines with a track record of applying quantitative and mechanism-based PK/PD modeling and simulation approaches to advance the discovery and development of therapeutics.
• Pharmaceutical industry experience required
• Experience using one or more modeling and simulation platforms (e.g., Monolix, Phoenix NLME, NONMEN, ADAPT, MATLAB, SimBiology, etc.)
• Strong theoretical and practical foundation in pharmacokinetics, including non-compartmental, compartmental, PK/PD and PBPK.
• Ability to learn new areas of biological sciences to develop quantitative and mechanistic PK/PD models for emerging therapeutic modalities.
• Familiarity with biotherapeutic modalities, including monoclonal and bispecific antibodies, gene therapy, CAR-T, siRNAs and other targeting agents preferred.

Does this sound like you? We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$150,500.00 - $245,500.00