Senior Small Molecule Analytical Scientist – Autophagy

Retro Biosciences, Inc.; Redwood City (CA); Hybrid; USD 175,000 - 210,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

401(k) 4% Match

Paid Parental Leave

Learning Stipend

Lunch & Snacks

Job summary

Retro develops therapies for aging-related diseases and is seeking a new member of the Autophagy team to lead analytical development and quality control for RTR242 as it progresses from Phase I toward Phase II. The role reports to the autophagy team leader and collaborates with the CMC lead and Quality team to craft and execute the analytical strategy.

You will develop and transfer UPLC/LC-MS methods, oversee outsourced QC activities, support raw material testing, and contribute to Module 3

Qualifications

• MS or PhD in analytical chemistry, medicinal chemistry, pharmaceutical sciences, or a related field.
• 7+ years of relevant industry experience in small-molecule analytical development in a regulated GxP environment.
• Experience developing, validating, transferring, and overseeing analytical methods for drug substance and drug product.

Responsibilities

• Drive analytical control strategy development for small molecule autophagy program, including test methods, specifications, stability, and impurity control as it advances.
• Develop analytical methods with hands-on UPLC and LC-MS work; characterize process impurities and degradation products.
• Transfer methods to external partners and oversee outsourced analytical and QC activities.
• Support identity testing for critical raw materials; method selection and vendor coordination.
• Support formulation development using analytical data to evaluate solubility, dissolution, and stability.
• Author and review analytical sections of Module 3 submissions (methods, specs, validation, stability, control strategy).
• Partner with CMC lead and quality team; manage external CDMOs and CROs.
• Support bioanalytical development for future generations of the compound.

Skills

Analytical development

Cross-functional comms

Regulatory documentation

Project management

Education

MS or PhD in analytical chemistry or related field

Tools

UPLC/HPLC

LC-MS method development

Stability testing

Data interpretation

CTD Module 3 experience

Job description

Retro develops therapies for aging-related diseases and is seeking a new member of the Autophagy team to lead analytical development and quality control for RTR242 as it progresses from Phase I toward Phase II. The role reports to the autophagy team leader and collaborates with the CMC lead and Quality team to craft and execute the analytical strategy.

You will develop and transfer UPLC/LC-MS methods, oversee outsourced QC activities, support raw material testing, and contribute to Module 3