Senior Scientist, Translational Research (Oncology TRC)

Bristol Myers Squibb; Cambridge (MA); On-site; USD 142,000 - 172,000; Full time

Job summary

Bristol Myers Squibb in Cambridge, MA is seeking an experienced Senior Scientist for Translational Research in Oncology TRC. The role focuses on designing and delivering data from biomarker and pharmacodynamic studies to guide clinical decisions.

The candidate will work across a matrixed organization, explore patient stratification and drug combinations, and lead bench studies from concept through IND-enabling work to clinical proof of concept.

Qualifications

• Bachelor’s degree required with 7+ years in academia or industry.
• Master’s degree with 5+ years experience is preferred.
• Ph.D. or equivalent advanced degree in life sciences with 2+ years experience preferred.

Responsibilities

• Develop biomarker, pharmacodynamic and target engagement assays.
• Address drug mechanism of action and sensitivity/resistance using current and new techniques.
• Utilize flow cytometry and multiplexed assays for human blood biomarker development.
• Use ELISA, MSD, Luminex and other biomarker platforms.
• Explore in vitro oncology models to study drug combinations and indications.
• Apply functional genomics tools (CRISPR, RNAi, ORF) to characterize targets.
• Coordinate with project teams and CROs for study design and oversight.
• Co-author non-clinical pharmacology reports and publications as needed.
• Understand departmental goals and development processes.
• Execute experiments independently and interpret data.
• Communicate findings clearly via emails, meetings, and reports.

Skills

Flow cytometry

Biomarker development

Data analysis

Education

Bachelor’s Degree

Master’s Degree

Ph.D. or equivalent

Tools

ELISA

MSD

Luminex

CRISPR

qPCR

Job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex‑vivo models of Cancer biology and Immuno‑oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world‑class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world‑class science, innovation, and business opportunities.

Position Summary

We are seeking an experienced individual with oncology discovery and/or translational expertise to join the Translational Research team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist that can work across a highly matrixed organization to advance programs from candidate optimization through IND enabling activities and ultimately to Clinical Proof of Concept studies. This individual will be dedicated to designing scientific studies and delivering data that impact clinical decision‑making for our programs. The candidate will explore patient stratification, drug combination, and/or biomarker concepts and execute bench studies that delivering data for Oncology TRC programs.

Position Responsibilities

• Develop biomarker, pharmacodynamic and target engagement assays.
• Use current and new techniques to address drug mechanism of action and sensitivity/resistance studies.
• Utilize flow cytometry and multiplexed assays for human blood biomarker development
• Utilize quantitative assays such as ELISA, MSD, Luminex, and other biomarker relevant assay platforms
• Utilize various in vitro oncology models/assays in order to explore drug combination studies and indication selection.
• Apply functional genomics tools (i.e. CRISPR, RNAi, ORF, etc.) in order to characterize oncogenic targets and drug mechanistic studies.
• Interact with project teams and contract laboratories for design and oversight of molecular, cellular and/or in vivo studies.
• Be responsible for co‑authoring non‑clinical pharmacology study reports and scientific publications, as needed.
• Be expected to understand departmental goals and development processes.
• Execute experiments independently, troubleshoot as needed, interpret and discuss data.
• Utilize excellent communication and interpersonal skills. Communicate via email, meetings and reports.

Basic Qualifications

• Bachelor’s Degree
  7+ years of academic and / or industry experience
• Master’s Degree
  5+ years of academic and / or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences
  2+ of academic and / or industry experience

Preferred Qualifications

• Ph.D. with post‑doctoral experience and/or 1‑3 years of industry experience, or BA or MA with at least 5‑7 years of industry experience in drug discovery or translational research in the pharma or biotech setting.
• Must be highly proficient in flow cytometry and the preclinical development of human blood‑based biomarker assays
• Experience performing biomarker‑focused laboratory work, including handling cell cultures and performing analysis of protein and DNA/RNA samples using a variety of methodologies including but not limited to MSD/ELISA, Luminex, RNAi, CRISPR, qPCR and primary cell isolation, culture and function assays is highly desired.
• Experienced in the design and development of cell‑based assays using various technology platforms, especially generation and characterization of patient‑derived material including organoid or tumoroid cultures and ex vivo manipulation and propagation is highly valued but not required
• Ability to conduct experimental work independently, with accurate, detailed record‑keeping.
• Ability to efficiently manage and prioritize multiple projects, coordinating in‑house research with collaborative work.
• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.
• Excellent oral and written communication skills. Ability to communicate well with peers and supervisors.
• Strong problem‑solving skills and understanding of relevant scientific principles.
• Ability to be flexible in case of changing priorities.

Compensation Overview

Cambridge Crossing $142,220 - $172,340

The starting pay range(s) listed above is for full‑time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability). U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year. Non‑exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays. Depending on eligibility, employees may also have access to additional time‑off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year’s Day. U.S.-based job seekers can explore full benefit offerings at https //careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https //careers.bms.com/ways‑of‑working.

Supporting People With Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information https //careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https //careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

R1605020 Senior Scientist, Translational Research (Oncology TRC)