Senior Scientist, Synthetic Biology

Pattern Biosciences; South San Francisco (CA); On-site; USD 158,000 - 207,000; Full time

Job summary

A leading company in South San Francisco is seeking a Senior Discovery Scientist in Synthetic Biology. You will develop next-generation cancer therapies using innovative biomolecular computing. This role involves designing genetic components and executing experiments to drive therapeutic advancements.

Qualifications

• 1-2 years of industry and/or postdoctoral research experience.
• Experience in design and testing of gene circuits in mammalian cells.

Responsibilities

• Design and construct genetic component libraries and logic scaffolds.
• Plan and execute in vitro and in vivo experiments.
• Characterize therapeutic candidates using various assays.

Skills

Gene Regulatory Processes

Gene Expression Mechanisms

High-Throughput Cloning

Mammalian Cell Culture

Fluorescent Microscopy

Flow Cytometry

Plate Reader Assays

Library Preparation

Education

PhD in Life Sciences

Tools

Next-Generation Sequencing

ELISA

RT-qPCR

Adeno-Associated Virus (AAV)

Job description

Direct message the job poster from Pattern Biosciences

Senior Discovery Scientist, Synthetic Biology

About Pattern Biosciences (www.patternbio.com)

Do you want to be at the forefront of a revolution in healthcare? At Pattern Biosciences, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in individual cells, our approach leads to curative therapies where the conventional one drug-one target paradigm has failed to deliver effective treatments. Our headquarters are in South San Francisco, and we are building a world-class team to translate two decades of progress in DNA computing and synthetic biology into the clinic.

About the Role

Are you passionate about working with cutting-edge technologies to develop next generation therapies? You will advance the pipeline of innovative cancer therapies harnessing our biomolecular computing platform. You will engineer genetic scaffolds to compute across multiple molecular inputs inside cells to program cancer cells for destruction with exquisite specificity. You will focus on individual sensor components, molecular computing scaffolds, and fully assembled therapeutic leads, as standalone DNA constructs and as genetic payloads of viral and non-viral delivery vectors.

What you'll do

• Design and construct barcoded genetic component libraries, logic scaffolds, effectors, and product leads
• Plan and execute in vitro and in vivo experiments to generate informative and clinically-translatable datasets to drive the design-build-test cycle of components and fully-assembled therapeutic leads
• Characterize component libraries and individual therapeutic candidates as naked and vectorized DNA in mammalian cell culture and in in vivo specimens using next-generation sequencing, fluorescent microscopy, flow cytometry, qPCR, and plate reader assays

What you'll bring

• Experience in the design, construction, and testing of gene circuits in mammalian cells
• Excellent knowledge of gene regulatory and gene expression processes and mechanisms in human cells, and the ability to translate this knowledge into actionable genetic designs
• Deep knowledge in experimental planning and execution of high-throughput cloning of barcoded libraries and individual genetic constructs using “Golden Gate”, Gibson assembly, yeast homologous recombination, restriction-ligation
• Experience in mammalian cell culture, fluorescent microscopy, flow cytometry, cell sorting, plate reader assays including ELISA, and RT-qPCR assays
• Hands-on experience in library preparation for next-generation sequencing
• Experience working with Adeno-Associated virus (AAV) vectors is an advantage

Who You Are

• PhD degree in life sciences including genetics, cancer biology, bioengineering and related fields
• 1-2 years of industry and/or postdoctoral research experience
• Track record demonstrating creativity and passion for science and patient care
• Desire and ability to operate in a high growth environment and deliver results within specified timelines and budgets

This is an in person role based at our headquarters in South San Francisco

To apply, please send a cover letter and a CV to [e-mail]

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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