Senior Scientist, Structural Biology — Target Druggability

Schrödinger; Framingham (MA); On-site; USD 135,000 - 190,000; Full time

Benefits offered by this job

Stock options

Healthcare (dental and vision)

401k

Pre-tax commuter benefits

Flexible work schedule

Parental leave

Catered meals

Paid vacation

Job summary

Schrödinger seeks a Senior or Principal Scientist in Structural Biology to join our Therapeutics Group and lead target tractability work. You will define tractability strategies, identify novel binding sites, and design and supervise experimental campaigns bridging computation and hands-on experiments.

You will collaborate with Molecular Pharmacologists, Biologists, Medicinal Chemists, and Computational Chemists to advance cryptic pocket discovery and validate approaches across difficult targets.

Qualifications

• PhD in Structural Biology, Biophysics, Computational Chemistry, or related field.
• Deep experience in structure-based drug design and cryptic pocket identification.
• Fluent in AI-based predictions and MD-based conformational sampling.
• Experience designing and interpreting cryo-EM and X-ray crystallography experiments.

Responsibilities

• Define druggability hypotheses by integrating structural, computational, biophysical, and pharmacological evidence.
• Apply computational methods and AI/ML for binding site identification and pocket druggability scoring.
• Translate insights into actionable hypotheses for medicinal chemistry and biology teams.
• Present target tractability assessments to project teams and leadership.
• Lead experimental structural biology efforts, collaborating with internal teams and CROs.
• Contribute to Schrödinger’s platform strategy and software/methods development.

Skills

Structural biology

Biophysics

Computational chemistry

Cryo-EM

X-ray crystallography

AI/ML methods

Druggability assessment

Education

PhD or equivalent

Tools

Glide

FEP+

BioLuminate

Prime

Job description

Schrödinger seeks a Senior or Principal Scientist in Structural Biology to join our Therapeutics Group and lead target tractability work. You will define tractability strategies, identify novel binding sites, and design and supervise experimental campaigns bridging computation and hands-on experiments.

You will collaborate with Molecular Pharmacologists, Biologists, Medicinal Chemists, and Computational Chemists to advance cryptic pocket discovery and validate approaches across difficult targets.