Senior Scientist, Small Molecule Process Development

EyeBio; Rahway (NJ); On-site; USD 117,000 - 184,000; Full time

Benefits offered by this job

Annual bonus

Long-term incentive

Medical Insurance

Retirement benefits (401(k))

Paid holidays/vacation/sick days

Job summary

Merck is seeking a Senior Scientist to provide technical leadership across late-stage small molecule drug substance development. The role spans lab, pilot plant, and manufacturing settings, influencing process design, transfers, and lifecycle improvements.

The candidate will apply DoE, QRM/QbD, and first-principles modeling to ensure robust, compliant processes while collaborating with internal teams and external partners to drive commercialization and continuous improvement.

Qualifications

• Ph.D. in Chemical Engineering or related field.
• BS or MS in Chemical Engineering with 5+ years of relevant industrial experience.
• Experience in chemical process development, commercialization, or manufacturing support of small molecule pharmaceutical processes.
• Strong communication and project management skills.
• Commitment to safety, quality, and compliance.

Responsibilities

• Lead process understanding and commercialization activities for small molecule drug substance manufacturing.
• Design and execute DoE-based experiments using QRM and QbD principles.
• Apply statistical methods to establish process robustness and control strategies.
• Develop and communicate technical recommendations to cross-functional teams and senior leadership.
• Support technology transfer from development to pilot and commercial facilities.
• Prepare technical reports, validation documents, and regulatory filing content.
• Provide leadership during PPQ, validation, and manufacturing campaigns.
• Lead investigations, risk assessments, deviations, and CAPAs.
• Collaborate with internal and external partners to resolve technical challenges.

Skills

Small molecule manufacturing

Process development

Experiment design

Communication

Team collaboration

Technical writing

Safety and compliance

Education

PhD in Chemical Engineering

BS/MS in Chemical Engineering with 5+ years experience

Tools

JMP

Minitab

Python

Job description

Merck is seeking a Senior Scientist to provide technical leadership across late-stage small molecule drug substance development. The role spans lab, pilot plant, and manufacturing settings, influencing process design, transfers, and lifecycle improvements.

The candidate will apply DoE, QRM/QbD, and first-principles modeling to ensure robust, compliant processes while collaborating with internal teams and external partners to drive commercialization and continuous improvement.